VAMP1 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

VAMP1

vesicle-associated membrane protein 1 (synaptobrevin 1); Involved in the targeting and/or fusion of transport vesicles to their target membrane (118 aa)

Predicted Functional Partners:

SNAP23

0.997

STX4

0.993

STX1B

0.990

STX2

0.983

STX3

0.983

VAPA

0.979

STX1A

0.975

YKT6

0.945

UBC

0.941

STX5

0.926

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SNAP23	STX1A	ENSP00000249647	ENSP00000222812	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 1A (brain)	0.887
SNAP23	STX1B	ENSP00000249647	ENSP00000215095	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	0.992
SNAP23	STX2	ENSP00000249647	ENSP00000376178	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm	0.999
SNAP23	STX3	ENSP00000249647	ENSP00000338562	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones	0.999
SNAP23	STX4	ENSP00000249647	ENSP00000317714	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones	0.999
SNAP23	STX5	ENSP00000249647	ENSP00000294179	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity)	0.896
SNAP23	UBC	ENSP00000249647	ENSP00000344818	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	ubiquitin C	0.923
SNAP23	VAMP1	ENSP00000249647	ENSP00000379602	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	vesicle-associated membrane protein 1 (synaptobrevin 1); Involved in the targeting and/or fusion of transport vesicles to their target membrane	0.997
SNAP23	VAPA	ENSP00000249647	ENSP00000345656	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking	0.764
SNAP23	YKT6	ENSP00000249647	ENSP00000223369	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity	0.815
STX1A	SNAP23	ENSP00000222812	ENSP00000249647	syntaxin 1A (brain)	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	0.887
STX1A	STX5	ENSP00000222812	ENSP00000294179	syntaxin 1A (brain)	syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity)	0.740
STX1A	VAMP1	ENSP00000222812	ENSP00000379602	syntaxin 1A (brain)	vesicle-associated membrane protein 1 (synaptobrevin 1); Involved in the targeting and/or fusion of transport vesicles to their target membrane	0.975
STX1A	VAPA	ENSP00000222812	ENSP00000345656	syntaxin 1A (brain)	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking	0.824
STX1A	YKT6	ENSP00000222812	ENSP00000223369	syntaxin 1A (brain)	YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity	0.799
STX1B	SNAP23	ENSP00000215095	ENSP00000249647	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	synaptosomal-associated protein, 23kDa; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion	0.992
STX1B	STX5	ENSP00000215095	ENSP00000294179	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity)	0.802
STX1B	UBC	ENSP00000215095	ENSP00000344818	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	ubiquitin C	0.514
STX1B	VAMP1	ENSP00000215095	ENSP00000379602	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	vesicle-associated membrane protein 1 (synaptobrevin 1); Involved in the targeting and/or fusion of transport vesicles to their target membrane	0.990
STX1B	VAPA	ENSP00000215095	ENSP00000345656	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking	0.853

page 1 of 5

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About