node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ETV6 | GATA1 | ENSP00000379658 | ENSP00000365858 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells | 0.925 |
ETV6 | KAT5 | ENSP00000379658 | ENSP00000340330 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | K(lysine) acetyltransferase 5 | 0.916 |
ETV6 | MAPK1 | ENSP00000379658 | ENSP00000215832 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.855 |
ETV6 | MAPK3 | ENSP00000379658 | ENSP00000263025 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.853 |
ETV6 | NCOR1 | ENSP00000379658 | ENSP00000268712 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.846 |
ETV6 | NOTCH1 | ENSP00000379658 | ENSP00000277541 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.894 |
ETV6 | NOTCH2 | ENSP00000379658 | ENSP00000256646 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | notch 2 | 0.852 |
ETV6 | NOTCH3 | ENSP00000379658 | ENSP00000263388 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.857 |
ETV6 | RUNX1 | ENSP00000379658 | ENSP00000300305 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | runt-related transcription factor 1 | 0.850 |
ETV6 | UBC | ENSP00000379658 | ENSP00000344818 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | ubiquitin C | 0.907 |
GATA1 | ETV6 | ENSP00000365858 | ENSP00000379658 | GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | 0.925 |
GATA1 | MAPK1 | ENSP00000365858 | ENSP00000215832 | GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells | mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.681 |
GATA1 | MAPK3 | ENSP00000365858 | ENSP00000263025 | GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells | mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.681 |
GATA1 | NCOR1 | ENSP00000365858 | ENSP00000268712 | GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.430 |
GATA1 | NOTCH1 | ENSP00000365858 | ENSP00000277541 | GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.534 |
GATA1 | RUNX1 | ENSP00000365858 | ENSP00000300305 | GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells | runt-related transcription factor 1 | 0.986 |
KAT5 | ETV6 | ENSP00000340330 | ENSP00000379658 | K(lysine) acetyltransferase 5 | ets variant 6; Transcriptional repressor; binds to the DNA sequence 5’- CCGGAAGT-3’ | 0.916 |
KAT5 | NCOR1 | ENSP00000340330 | ENSP00000268712 | K(lysine) acetyltransferase 5 | nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors | 0.580 |
KAT5 | NOTCH1 | ENSP00000340330 | ENSP00000277541 | K(lysine) acetyltransferase 5 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.898 |
KAT5 | UBC | ENSP00000340330 | ENSP00000344818 | K(lysine) acetyltransferase 5 | ubiquitin C | 0.981 |