| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASRGL1 | CXorf56 | ENSP00000301776 | ENSP00000360652 | asparaginase like 1; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine | chromosome X open reading frame 56 | 0.564 |
| ASRGL1 | KIAA2013 | ENSP00000301776 | ENSP00000365756 | asparaginase like 1; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine | KIAA2013 | 0.607 |
| ASRGL1 | PDXDC1 | ENSP00000301776 | ENSP00000379691 | asparaginase like 1; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine | pyridoxal-dependent decarboxylase domain containing 1 | 0.550 |
| ASRGL1 | UBC | ENSP00000301776 | ENSP00000344818 | asparaginase like 1; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine | ubiquitin C | 0.636 |
| ASRGL1 | WRB | ENSP00000301776 | ENSP00000327716 | asparaginase like 1; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine | tryptophan rich basic protein; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane | 0.532 |
| ATP6V1H | PDXDC1 | ENSP00000352522 | ENSP00000379691 | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes | pyridoxal-dependent decarboxylase domain containing 1 | 0.538 |
| ATP6V1H | UBC | ENSP00000352522 | ENSP00000344818 | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes | ubiquitin C | 0.984 |
| BFAR | NOMO1 | ENSP00000261658 | ENSP00000287667 | bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors | NODAL modulator 1; May antagonize Nodal signaling (By similarity) | 0.758 |
| BFAR | PDXDC1 | ENSP00000261658 | ENSP00000379691 | bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors | pyridoxal-dependent decarboxylase domain containing 1 | 0.862 |
| BFAR | UBC | ENSP00000261658 | ENSP00000344818 | bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors | ubiquitin C | 0.829 |
| CXorf56 | ASRGL1 | ENSP00000360652 | ENSP00000301776 | chromosome X open reading frame 56 | asparaginase like 1; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine | 0.564 |
| CXorf56 | PDXDC1 | ENSP00000360652 | ENSP00000379691 | chromosome X open reading frame 56 | pyridoxal-dependent decarboxylase domain containing 1 | 0.585 |
| CXorf56 | UBC | ENSP00000360652 | ENSP00000344818 | chromosome X open reading frame 56 | ubiquitin C | 0.620 |
| HTRA2 | PDXDC1 | ENSP00000258080 | ENSP00000379691 | HtrA serine peptidase 2; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive | pyridoxal-dependent decarboxylase domain containing 1 | 0.574 |
| HTRA2 | UBC | ENSP00000258080 | ENSP00000344818 | HtrA serine peptidase 2; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive | ubiquitin C | 0.986 |
| KIAA2013 | ASRGL1 | ENSP00000365756 | ENSP00000301776 | KIAA2013 | asparaginase like 1; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine | 0.607 |
| KIAA2013 | PDXDC1 | ENSP00000365756 | ENSP00000379691 | KIAA2013 | pyridoxal-dependent decarboxylase domain containing 1 | 0.642 |
| MIF4GD | PDXDC1 | ENSP00000245551 | ENSP00000379691 | MIF4G domain containing; Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation | pyridoxal-dependent decarboxylase domain containing 1 | 0.644 |
| NOMO1 | BFAR | ENSP00000287667 | ENSP00000261658 | NODAL modulator 1; May antagonize Nodal signaling (By similarity) | bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors | 0.758 |
| NOMO1 | PDXDC1 | ENSP00000287667 | ENSP00000379691 | NODAL modulator 1; May antagonize Nodal signaling (By similarity) | pyridoxal-dependent decarboxylase domain containing 1 | 0.861 |
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