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STRINGSTRING
C9orf69 C9orf69 SEPT10 SEPT10 SEPT3 SEPT3 SEPT14 SEPT14 BRSK2 BRSK2 SEPT8 SEPT8 BRSK1 BRSK1 UBC UBC PDE5A PDE5A SEPT6 SEPT6 SEPT11 SEPT11
"SEPT3" - septin 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
SEPT3septin 3; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (358 aa)    
Predicted Functional Partners:
SEPT6
septin 6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication (434 aa)
        score_image score_image score_image score_image 0.782
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.684
PDE5A
phosphodiesterase 5A, cGMP-specific; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP (875 aa)
            score_image   0.649
C9orf69
chromosome 9 open reading frame 69; Plays a role in cell proliferation by promoting progression into S phase. Promotes human herpesvirus 1 (HHV-1) proliferation (139 aa)
        score_image   score_image   0.645
SEPT8
septin 8; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (483 aa)
        score_image score_image score_image score_image 0.632
SEPT14
septin 14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) (432 aa)
        score_image score_image score_image score_image 0.629
SEPT10
septin 10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential) (454 aa)
        score_image score_image score_image score_image 0.627
SEPT11
septin 11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy (429 aa)
        score_image score_image score_image score_image 0.627
BRSK2
BR serine/threonine kinase 2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regu [...] (668 aa)
        score_image   score_image   0.623
BRSK1
BR serine/threonine kinase 1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at ’Thr-529’ and ’Ser-579’. Also regulates neuron polarization by mediating phosphorylation of WEE1 at ’Ser-642’ in post-mitotic neurons, leading to down-regulate WEE1 activit [...] (778 aa)
        score_image   score_image   0.623
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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