IQSEC2 protein (Homo sapiens) - STRING network view

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Score

IQSEC2

IQ motif and Sec7 domain 2 (1488 aa)

Predicted Functional Partners:

GPR173

0.761

DCC

0.752

IGDCC3

0.752

NEO1

0.752

TSPYL2

0.737

SLIT3

0.708

SLIT2

0.708

SLIT1

0.708

LRRC3B

0.691

LRRC3C

0.691

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCC	IQSEC2	ENSP00000389140	ENSP00000379712	deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene	IQ motif and Sec7 domain 2	0.752
DCC	LRRC3B	ENSP00000389140	ENSP00000379880	deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene	leucine rich repeat containing 3B	0.455
DCC	LRRC3C	ENSP00000389140	ENSP00000367157	deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene	leucine rich repeat containing 3C	0.455
DCC	NEO1	ENSP00000389140	ENSP00000261908	deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene	neogenin 1; May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues	0.905
DCC	SLIT1	ENSP00000389140	ENSP00000266058	deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene	slit homolog 1 (Drosophila); Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb	0.959
DCC	SLIT2	ENSP00000389140	ENSP00000422591	deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene	slit homolog 2 (Drosophila); Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once [...]	0.964
DCC	SLIT3	ENSP00000389140	ENSP00000430333	deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene	slit homolog 3 (Drosophila); May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors	0.966
GPR173	IQSEC2	ENSP00000331600	ENSP00000379712	G protein-coupled receptor 173; Orphan receptor	IQ motif and Sec7 domain 2	0.761
GPR173	TSPYL2	ENSP00000331600	ENSP00000364591	G protein-coupled receptor 173; Orphan receptor	TSPY-like 2; Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression	0.675
IGDCC3	IQSEC2	ENSP00000332773	ENSP00000379712	immunoglobulin superfamily, DCC subclass, member 3	IQ motif and Sec7 domain 2	0.752
IGDCC3	LRRC3B	ENSP00000332773	ENSP00000379880	immunoglobulin superfamily, DCC subclass, member 3	leucine rich repeat containing 3B	0.818
IGDCC3	LRRC3C	ENSP00000332773	ENSP00000367157	immunoglobulin superfamily, DCC subclass, member 3	leucine rich repeat containing 3C	0.818
IGDCC3	SLIT1	ENSP00000332773	ENSP00000266058	immunoglobulin superfamily, DCC subclass, member 3	slit homolog 1 (Drosophila); Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb	0.818
IGDCC3	SLIT2	ENSP00000332773	ENSP00000422591	immunoglobulin superfamily, DCC subclass, member 3	slit homolog 2 (Drosophila); Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once [...]	0.818
IGDCC3	SLIT3	ENSP00000332773	ENSP00000430333	immunoglobulin superfamily, DCC subclass, member 3	slit homolog 3 (Drosophila); May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors	0.818
IQSEC2	DCC	ENSP00000379712	ENSP00000389140	IQ motif and Sec7 domain 2	deleted in colorectal carcinoma; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene	0.752
IQSEC2	GPR173	ENSP00000379712	ENSP00000331600	IQ motif and Sec7 domain 2	G protein-coupled receptor 173; Orphan receptor	0.761
IQSEC2	IGDCC3	ENSP00000379712	ENSP00000332773	IQ motif and Sec7 domain 2	immunoglobulin superfamily, DCC subclass, member 3	0.752
IQSEC2	LRRC3B	ENSP00000379712	ENSP00000379880	IQ motif and Sec7 domain 2	leucine rich repeat containing 3B	0.691
IQSEC2	LRRC3C	ENSP00000379712	ENSP00000367157	IQ motif and Sec7 domain 2	leucine rich repeat containing 3C	0.691

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