node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDKN2A | GNE | ENSP00000394932 | ENSP00000379839 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.802 |
CDKN2A | UBC | ENSP00000394932 | ENSP00000344818 | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | ubiquitin C | 0.998 |
CMAS | GNE | ENSP00000229329 | ENSP00000379839 | cytidine monophosphate N-acetylneuraminic acid synthetase; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5’-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.855 |
CMAS | NANS | ENSP00000229329 | ENSP00000210444 | cytidine monophosphate N-acetylneuraminic acid synthetase; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5’-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) | N-acetylneuraminic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively | 0.996 |
CMAS | UBC | ENSP00000229329 | ENSP00000344818 | cytidine monophosphate N-acetylneuraminic acid synthetase; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5’-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) | ubiquitin C | 0.729 |
GNE | CDKN2A | ENSP00000379839 | ENSP00000394932 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein | 0.802 |
GNE | CMAS | ENSP00000379839 | ENSP00000229329 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | cytidine monophosphate N-acetylneuraminic acid synthetase; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5’-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) | 0.855 |
GNE | LDHB | ENSP00000379839 | ENSP00000229319 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | lactate dehydrogenase B | 0.828 |
GNE | LDHC | ENSP00000379839 | ENSP00000280704 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | lactate dehydrogenase C; Possible role in sperm motility | 0.828 |
GNE | NANS | ENSP00000379839 | ENSP00000210444 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | N-acetylneuraminic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively | 0.994 |
GNE | NPL | ENSP00000379839 | ENSP00000258317 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase); Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity) | 0.940 |
GNE | RNF38 | ENSP00000379839 | ENSP00000259605 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | ring finger protein 38 | 0.869 |
GNE | UAP1 | ENSP00000379839 | ENSP00000356903 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | UDP-N-acteylglucosamine pyrophosphorylase 1; Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P | 0.931 |
GNE | UAP1L1 | ENSP00000379839 | ENSP00000386935 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 | 0.914 |
GNE | UBC | ENSP00000379839 | ENSP00000344818 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | ubiquitin C | 0.835 |
LDHB | GNE | ENSP00000229319 | ENSP00000379839 | lactate dehydrogenase B | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.828 |
LDHB | UBC | ENSP00000229319 | ENSP00000344818 | lactate dehydrogenase B | ubiquitin C | 0.991 |
LDHC | GNE | ENSP00000280704 | ENSP00000379839 | lactate dehydrogenase C; Possible role in sperm motility | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.828 |
NANS | CMAS | ENSP00000210444 | ENSP00000229329 | N-acetylneuraminic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively | cytidine monophosphate N-acetylneuraminic acid synthetase; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5’-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) | 0.996 |
NANS | GNE | ENSP00000210444 | ENSP00000379839 | N-acetylneuraminic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.994 |