node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IGDCC3 | IQSEC1 | ENSP00000332773 | ENSP00000273221 | immunoglobulin superfamily, DCC subclass, member 3 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | 0.752 |
IGDCC3 | IQSEC2 | ENSP00000332773 | ENSP00000379712 | immunoglobulin superfamily, DCC subclass, member 3 | IQ motif and Sec7 domain 2 | 0.752 |
IGDCC3 | IQSEC3 | ENSP00000332773 | ENSP00000315662 | immunoglobulin superfamily, DCC subclass, member 3 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | 0.752 |
IGDCC3 | LRRC3B | ENSP00000332773 | ENSP00000379880 | immunoglobulin superfamily, DCC subclass, member 3 | leucine rich repeat containing 3B | 0.818 |
IGSF9B | LRRC3B | ENSP00000317980 | ENSP00000379880 | immunoglobulin superfamily, member 9B | leucine rich repeat containing 3B | 0.718 |
IHH | LRRC3B | ENSP00000295731 | ENSP00000379880 | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | leucine rich repeat containing 3B | 0.690 |
IQSEC1 | IGDCC3 | ENSP00000273221 | ENSP00000332773 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | immunoglobulin superfamily, DCC subclass, member 3 | 0.752 |
IQSEC1 | LRRC3B | ENSP00000273221 | ENSP00000379880 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | leucine rich repeat containing 3B | 0.782 |
IQSEC2 | IGDCC3 | ENSP00000379712 | ENSP00000332773 | IQ motif and Sec7 domain 2 | immunoglobulin superfamily, DCC subclass, member 3 | 0.752 |
IQSEC2 | LRRC3B | ENSP00000379712 | ENSP00000379880 | IQ motif and Sec7 domain 2 | leucine rich repeat containing 3B | 0.691 |
IQSEC3 | IGDCC3 | ENSP00000315662 | ENSP00000332773 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | immunoglobulin superfamily, DCC subclass, member 3 | 0.752 |
IQSEC3 | LRRC3B | ENSP00000315662 | ENSP00000379880 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | leucine rich repeat containing 3B | 0.691 |
LRRC3B | IGDCC3 | ENSP00000379880 | ENSP00000332773 | leucine rich repeat containing 3B | immunoglobulin superfamily, DCC subclass, member 3 | 0.818 |
LRRC3B | IGSF9B | ENSP00000379880 | ENSP00000317980 | leucine rich repeat containing 3B | immunoglobulin superfamily, member 9B | 0.718 |
LRRC3B | IHH | ENSP00000379880 | ENSP00000295731 | leucine rich repeat containing 3B | Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity) | 0.690 |
LRRC3B | IQSEC1 | ENSP00000379880 | ENSP00000273221 | leucine rich repeat containing 3B | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | 0.782 |
LRRC3B | IQSEC2 | ENSP00000379880 | ENSP00000379712 | leucine rich repeat containing 3B | IQ motif and Sec7 domain 2 | 0.691 |
LRRC3B | IQSEC3 | ENSP00000379880 | ENSP00000315662 | leucine rich repeat containing 3B | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | 0.691 |
LRRC3B | ROBO1 | ENSP00000379880 | ENSP00000420321 | leucine rich repeat containing 3B | roundabout, axon guidance receptor, homolog 1 (Drosophila); Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development | 0.736 |
LRRC3B | ROBO2 | ENSP00000379880 | ENSP00000417335 | leucine rich repeat containing 3B | roundabout, axon guidance receptor, homolog 2 (Drosophila); Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development | 0.717 |