Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | TMEM106B | transmembrane protein 106B (274 aa) | ||||||||||||
Predicted Functional Partners:
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 | UBC | ubiquitin C (685 aa) |
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0.921 | ||||||||||
 | TARDBP | TAR DNA binding protein (414 aa) |
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0.751 | ||||||||||
 | TRDN | triadin; May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its functional coupling with the ryanodine receptor (By similarity) (729 aa) |
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0.681 | ||||||||||
 | MAP6 | microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity (813 aa) |
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0.630 | |||||||||
 | GRN | granulin (593 aa) |
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0.608 | ||||||||||
 | ARL8A | ADP-ribosylation factor-like 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity) (186 aa) |
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0.593 | |||||||||
 | C9orf72 | chromosome 9 open reading frame 72 (481 aa) |
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0.561 | ||||||||||
 | TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1; May be a scaffold component in the postsynaptic density (By similarity) (1861 aa) |
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0.534 | ||||||||||
 | ARL8B | ADP-ribosylation factor-like 8B; May play a role in lysosome motility (PubMed-16537643). May play a role in chromosome segregation (PubMed-15331635) (186 aa) |
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0.524 | |||||||||
 | PLXNC1 | plexin C1; Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity) (1568 aa) |
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0.518 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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