| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CNTF | ICA1 | ENSP00000355370 | ENSP00000379908 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | 0.615 |
| CNTF | STK16 | ENSP00000355370 | ENSP00000379964 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | serine/threonine kinase 16; Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins | 0.615 |
| ERGIC1 | ICA1 | ENSP00000377374 | ENSP00000379908 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | 0.612 |
| GAD2 | ICA1 | ENSP00000259271 | ENSP00000379908 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | 0.583 |
| GAD2 | PTPRN | ENSP00000259271 | ENSP00000295718 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.919 |
| ICA1 | CNTF | ENSP00000379908 | ENSP00000355370 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | 0.615 |
| ICA1 | ERGIC1 | ENSP00000379908 | ENSP00000377374 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1; Possible role in transport between endoplasmic reticulum and Golgi | 0.612 |
| ICA1 | GAD2 | ENSP00000379908 | ENSP00000259271 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.583 |
| ICA1 | MKKS | ENSP00000379908 | ENSP00000246062 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | McKusick-Kaufman syndrome; Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis | 0.615 |
| ICA1 | PIK3R2 | ENSP00000379908 | ENSP00000222254 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | phosphoinositide-3-kinase, regulatory subunit 2 (beta); Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane | 0.608 |
| ICA1 | PTPRN | ENSP00000379908 | ENSP00000295718 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | 0.602 |
| ICA1 | RAB2A | ENSP00000379908 | ENSP00000262646 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | RAB2A, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex | 0.819 |
| ICA1 | RAB2B | ENSP00000379908 | ENSP00000380869 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | 0.753 |
| ICA1 | STK16 | ENSP00000379908 | ENSP00000379964 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | serine/threonine kinase 16; Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins | 0.615 |
| ICA1 | ZNF254 | ENSP00000379908 | ENSP00000349494 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | zinc finger protein 254; May be involved in transcriptional regulation | 0.556 |
| MKKS | ICA1 | ENSP00000246062 | ENSP00000379908 | McKusick-Kaufman syndrome; Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | 0.615 |
| MKKS | STK16 | ENSP00000246062 | ENSP00000379964 | McKusick-Kaufman syndrome; Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis | serine/threonine kinase 16; Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins | 0.615 |
| PIK3R2 | ICA1 | ENSP00000222254 | ENSP00000379908 | phosphoinositide-3-kinase, regulatory subunit 2 (beta); Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | 0.608 |
| PTPRN | GAD2 | ENSP00000295718 | ENSP00000259271 | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.919 |
| PTPRN | ICA1 | ENSP00000295718 | ENSP00000379908 | protein tyrosine phosphatase, receptor type, N; Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | 0.602 |
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