LEUTX protein (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Score

LEUTX

leucine twenty homeobox (168 aa)

Predicted Functional Partners:

DPRX

0.754

RAX2

0.751

DUXA

0.737

TPRX1

0.727

SEBOX

0.712

SHH

0.697

IHH

0.697

DHH

0.697

SIX6

0.628

SIX5

0.607

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHH	LEUTX	ENSP00000266991	ENSP00000380053	desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development	leucine twenty homeobox	0.697
DPRX	LEUTX	ENSP00000365838	ENSP00000380053	divergent-paired related homeobox; Putative transcription factor (By similarity)	leucine twenty homeobox	0.754
DPRX	RAX2	ENSP00000365838	ENSP00000450687	divergent-paired related homeobox; Putative transcription factor (By similarity)	retina and anterior neural fold homeobox 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter	0.561
DPRX	TPRX1	ENSP00000365838	ENSP00000323455	divergent-paired related homeobox; Putative transcription factor (By similarity)	tetra-peptide repeat homeobox 1	0.700
DUXA	LEUTX	ENSP00000452398	ENSP00000380053	double homeobox A; Putative transcription factor (By similarity)	leucine twenty homeobox	0.737
DUXA	SIX5	ENSP00000452398	ENSP00000316842	double homeobox A; Putative transcription factor (By similarity)	SIX homeobox 5; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5’-GGTGTCAG-3’ motif present in the ARE regulatory element of ATP1A1. Binds a 5’- TCA[AG][AG]TTNC-3’ motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity)	0.413
DUXA	SIX6	ENSP00000452398	ENSP00000328596	double homeobox A; Putative transcription factor (By similarity)	SIX homeobox 6; May be involved in eye development	0.427
DUXA	TPRX1	ENSP00000452398	ENSP00000323455	double homeobox A; Putative transcription factor (By similarity)	tetra-peptide repeat homeobox 1	0.636
IHH	LEUTX	ENSP00000295731	ENSP00000380053	Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity)	leucine twenty homeobox	0.697
LEUTX	DHH	ENSP00000380053	ENSP00000266991	leucine twenty homeobox	desert hedgehog; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development	0.697
LEUTX	DPRX	ENSP00000380053	ENSP00000365838	leucine twenty homeobox	divergent-paired related homeobox; Putative transcription factor (By similarity)	0.754
LEUTX	DUXA	ENSP00000380053	ENSP00000452398	leucine twenty homeobox	double homeobox A; Putative transcription factor (By similarity)	0.737
LEUTX	IHH	ENSP00000380053	ENSP00000295731	leucine twenty homeobox	Indian hedgehog; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification- may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity)	0.697
LEUTX	RAX2	ENSP00000380053	ENSP00000450687	leucine twenty homeobox	retina and anterior neural fold homeobox 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter	0.751
LEUTX	SEBOX	ENSP00000380053	ENSP00000416240	leucine twenty homeobox	SEBOX homeobox; Probable transcription factor involved in the control of specification of mesoderm and endoderm (By similarity)	0.712
LEUTX	SHH	ENSP00000380053	ENSP00000297261	leucine twenty homeobox	sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...]	0.697
LEUTX	SIX5	ENSP00000380053	ENSP00000316842	leucine twenty homeobox	SIX homeobox 5; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5’-GGTGTCAG-3’ motif present in the ARE regulatory element of ATP1A1. Binds a 5’- TCA[AG][AG]TTNC-3’ motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity)	0.607
LEUTX	SIX6	ENSP00000380053	ENSP00000328596	leucine twenty homeobox	SIX homeobox 6; May be involved in eye development	0.628
LEUTX	TPRX1	ENSP00000380053	ENSP00000323455	leucine twenty homeobox	tetra-peptide repeat homeobox 1	0.727
RAX2	DPRX	ENSP00000450687	ENSP00000365838	retina and anterior neural fold homeobox 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter	divergent-paired related homeobox; Putative transcription factor (By similarity)	0.561

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