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PAFAH1B1 PAFAH1B1 DYNC1LI2 DYNC1LI2 DYNC2H1 DYNC2H1 DCTN1 DCTN1 DYNC1I2 DYNC1I2 DCTN2 DCTN2 DYNC1H1 DYNC1H1 DYNLL1 DYNLL1 DYNLL2 DYNLL2 DYNLRB1 DYNLRB1 DYNC2LI1 DYNC2LI1
"DYNC1I2" - dynein, cytoplasmic 1, intermediate chain 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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co-expression
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protein homology
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Score
DYNC1I2dynein, cytoplasmic 1, intermediate chain 2 (638 aa)    
Predicted Functional Partners:
DYNLRB1
dynein, light chain, roadblock-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (96 aa)
        score_image score_image score_image   0.986
DCTN1
dynactin 1 (1278 aa)
      score_image score_image score_image score_image   0.983
DYNC1H1
dynein, cytoplasmic 1, heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (4646 aa)
      score_image score_image score_image score_image   0.981
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (492 aa)
        score_image score_image score_image   0.980
DYNLL1
dynein, light chain, LC8-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (89 aa)
        score_image score_image score_image   0.972
DYNLL2
dynein, light chain, LC8-type 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity) (89 aa)
        score_image score_image score_image   0.971
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] (410 aa)
          score_image score_image   0.969
DYNC2H1
dynein, cytoplasmic 2, heavy chain 1 (4314 aa)
      score_image   score_image score_image   0.964
DYNC2LI1
dynein, cytoplasmic 2, light intermediate chain 1 (351 aa)
          score_image score_image   0.959
DCTN2
dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (406 aa)
          score_image score_image   0.955
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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