node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPN12 | FHAD1 | ENSP00000331636 | ENSP00000365167 | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.463 |
CAPN12 | MBLAC1 | ENSP00000331636 | ENSP00000381150 | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | metallo-beta-lactamase domain containing 1 | 0.572 |
CAPN12 | ZNF676 | ENSP00000331636 | ENSP00000380310 | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | zinc finger protein 676; May be involved in transcriptional regulation | 0.508 |
CTC1 | OBFC1 | ENSP00000313759 | ENSP00000224950 | CTS telomere maintenance complex component 1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites | oligonucleotide/oligosaccharide-binding fold containing 1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites | 0.994 |
CTC1 | ZNF676 | ENSP00000313759 | ENSP00000380310 | CTS telomere maintenance complex component 1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites | zinc finger protein 676; May be involved in transcriptional regulation | 0.725 |
FHAD1 | CAPN12 | ENSP00000365167 | ENSP00000331636 | forkhead-associated (FHA) phosphopeptide binding domain 1 | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | 0.463 |
FHAD1 | MBLAC1 | ENSP00000365167 | ENSP00000381150 | forkhead-associated (FHA) phosphopeptide binding domain 1 | metallo-beta-lactamase domain containing 1 | 0.707 |
FHAD1 | ZNF676 | ENSP00000365167 | ENSP00000380310 | forkhead-associated (FHA) phosphopeptide binding domain 1 | zinc finger protein 676; May be involved in transcriptional regulation | 0.566 |
KDM2A | ZNF676 | ENSP00000432786 | ENSP00000380310 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 676; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF676 | ENSP00000366271 | ENSP00000380310 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 676; May be involved in transcriptional regulation | 0.533 |
MBLAC1 | CAPN12 | ENSP00000381150 | ENSP00000331636 | metallo-beta-lactamase domain containing 1 | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | 0.572 |
MBLAC1 | FHAD1 | ENSP00000381150 | ENSP00000365167 | metallo-beta-lactamase domain containing 1 | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.707 |
MBLAC1 | ZNF676 | ENSP00000381150 | ENSP00000380310 | metallo-beta-lactamase domain containing 1 | zinc finger protein 676; May be involved in transcriptional regulation | 0.658 |
OBFC1 | CTC1 | ENSP00000224950 | ENSP00000313759 | oligonucleotide/oligosaccharide-binding fold containing 1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites | CTS telomere maintenance complex component 1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites | 0.994 |
OBFC1 | ZNF676 | ENSP00000224950 | ENSP00000380310 | oligonucleotide/oligosaccharide-binding fold containing 1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites | zinc finger protein 676; May be involved in transcriptional regulation | 0.567 |
RSPH10B2 | ZNF676 | ENSP00000297186 | ENSP00000380310 | radial spoke head 10 homolog B2 (Chlamydomonas) | zinc finger protein 676; May be involved in transcriptional regulation | 0.660 |
XRN1 | ZNF676 | ENSP00000264951 | ENSP00000380310 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 676; May be involved in transcriptional regulation | 0.543 |
ZDHHC20 | ZNF676 | ENSP00000371905 | ENSP00000380310 | zinc finger, DHHC-type containing 20 | zinc finger protein 676; May be involved in transcriptional regulation | 0.580 |
ZNF676 | CAPN12 | ENSP00000380310 | ENSP00000331636 | zinc finger protein 676; May be involved in transcriptional regulation | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | 0.508 |
ZNF676 | CTC1 | ENSP00000380310 | ENSP00000313759 | zinc finger protein 676; May be involved in transcriptional regulation | CTS telomere maintenance complex component 1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites | 0.725 |