| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD2BP2 | SMU1 | ENSP00000304903 | ENSP00000380336 | CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly | smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) | 0.773 |
| CD2BP2 | SRSF11 | ENSP00000304903 | ENSP00000359988 | CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly | serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing | 0.900 |
| CD2BP2 | YBX1 | ENSP00000304903 | ENSP00000361626 | CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly | Y box binding protein 1; Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at ’Lys-6’ and ’Lys-7’. Binds to promoters that contain a Y-box (5’-CTGATTGGCCAA-3’), such as MD [...] | 0.900 |
| IK | PHGDH | ENSP00000396301 | ENSP00000358417 | IK cytokine, down-regulator of HLA II; May bind to chromatin | phosphoglycerate dehydrogenase | 0.905 |
| IK | SAP18 | ENSP00000396301 | ENSP00000371973 | IK cytokine, down-regulator of HLA II; May bind to chromatin | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | 0.905 |
| IK | SMU1 | ENSP00000396301 | ENSP00000380336 | IK cytokine, down-regulator of HLA II; May bind to chromatin | smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) | 0.983 |
| IK | SRSF11 | ENSP00000396301 | ENSP00000359988 | IK cytokine, down-regulator of HLA II; May bind to chromatin | serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing | 0.892 |
| IK | UBC | ENSP00000396301 | ENSP00000344818 | IK cytokine, down-regulator of HLA II; May bind to chromatin | ubiquitin C | 0.889 |
| PHGDH | IK | ENSP00000358417 | ENSP00000396301 | phosphoglycerate dehydrogenase | IK cytokine, down-regulator of HLA II; May bind to chromatin | 0.905 |
| PHGDH | SAP18 | ENSP00000358417 | ENSP00000371973 | phosphoglycerate dehydrogenase | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | 0.906 |
| PHGDH | SMU1 | ENSP00000358417 | ENSP00000380336 | phosphoglycerate dehydrogenase | smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) | 0.898 |
| PHGDH | SRSF11 | ENSP00000358417 | ENSP00000359988 | phosphoglycerate dehydrogenase | serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing | 0.896 |
| PHGDH | UBC | ENSP00000358417 | ENSP00000344818 | phosphoglycerate dehydrogenase | ubiquitin C | 0.994 |
| SAP18 | IK | ENSP00000371973 | ENSP00000396301 | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | IK cytokine, down-regulator of HLA II; May bind to chromatin | 0.905 |
| SAP18 | PHGDH | ENSP00000371973 | ENSP00000358417 | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | phosphoglycerate dehydrogenase | 0.906 |
| SAP18 | SMU1 | ENSP00000371973 | ENSP00000380336 | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) | 0.892 |
| SAP18 | SRSF11 | ENSP00000371973 | ENSP00000359988 | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing | 0.666 |
| SAP18 | TFPI | ENSP00000371973 | ENSP00000233156 | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma | 0.809 |
| SAP18 | UBC | ENSP00000371973 | ENSP00000344818 | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | ubiquitin C | 0.925 |
| SMU1 | CD2BP2 | ENSP00000380336 | ENSP00000304903 | smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) | CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly | 0.773 |
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