node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHNAK | CAPN3 | ENSP00000367263 | ENSP00000380349 | AHNAK nucleoprotein; May be required for neuronal cell differentiation | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | 0.869 |
AHNAK | DYSF | ENSP00000367263 | ENSP00000386881 | AHNAK nucleoprotein; May be required for neuronal cell differentiation | dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) | 0.418 |
ALDOA | CAPN3 | ENSP00000336927 | ENSP00000380349 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | 0.806 |
BRAF | CAPN3 | ENSP00000288602 | ENSP00000380349 | v-raf murine sarcoma viral oncogene homolog B1 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | 0.913 |
BRAF | MAP3K1 | ENSP00000288602 | ENSP00000382423 | v-raf murine sarcoma viral oncogene homolog B1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | 0.964 |
BRAF | PRKCE | ENSP00000288602 | ENSP00000306124 | v-raf murine sarcoma viral oncogene homolog B1 | protein kinase C, epsilon; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITG [...] | 0.984 |
BRAF | RPS6KA2 | ENSP00000288602 | ENSP00000427015 | v-raf murine sarcoma viral oncogene homolog B1 | ribosomal protein S6 kinase, 90kDa, polypeptide 2; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells | 0.940 |
CAPN3 | AHNAK | ENSP00000380349 | ENSP00000367263 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | AHNAK nucleoprotein; May be required for neuronal cell differentiation | 0.869 |
CAPN3 | ALDOA | ENSP00000380349 | ENSP00000336927 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | 0.806 |
CAPN3 | BRAF | ENSP00000380349 | ENSP00000288602 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | v-raf murine sarcoma viral oncogene homolog B1 | 0.913 |
CAPN3 | CMYA5 | ENSP00000380349 | ENSP00000394770 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | cardiomyopathy associated 5 | 0.846 |
CAPN3 | DYSF | ENSP00000380349 | ENSP00000386881 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) | 0.892 |
CAPN3 | KRT26 | ENSP00000380349 | ENSP00000334798 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | keratin 26 | 0.964 |
CAPN3 | MAP3K1 | ENSP00000380349 | ENSP00000382423 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | 0.965 |
CAPN3 | PRKCE | ENSP00000380349 | ENSP00000306124 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | protein kinase C, epsilon; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITG [...] | 0.926 |
CAPN3 | RPS6KA2 | ENSP00000380349 | ENSP00000427015 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | ribosomal protein S6 kinase, 90kDa, polypeptide 2; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells | 0.927 |
CAPN3 | TTN | ENSP00000380349 | ENSP00000343764 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | titin | 0.998 |
CMYA5 | CAPN3 | ENSP00000394770 | ENSP00000380349 | cardiomyopathy associated 5 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | 0.846 |
CMYA5 | TTN | ENSP00000394770 | ENSP00000343764 | cardiomyopathy associated 5 | titin | 0.428 |
DYSF | AHNAK | ENSP00000386881 | ENSP00000367263 | dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) | AHNAK nucleoprotein; May be required for neuronal cell differentiation | 0.418 |