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STRINGSTRING
SLX4 SLX4 SPATA8 SPATA8 TRAPPC2L TRAPPC2L MEIOB MEIOB SPATA22 SPATA22 MEI1 MEI1 ASAP2 ASAP2 MED4 MED4 FKBP6 FKBP6 TEX11 TEX11 MND1 MND1
"SPATA22" - spermatogenesis associated 22 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
SPATA22spermatogenesis associated 22 (363 aa)    
Predicted Functional Partners:
MEIOB
meiosis specific with OB domains; May be involved in early meiosis (By similarity) (471 aa)
            score_image   0.634
MEI1
meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity) (1274 aa)
            score_image   0.603
TRAPPC2L
trafficking protein particle complex 2-like; May play a role in vesicular transport from endoplasmic reticulum to Golgi (140 aa)
        score_image       0.571
MED4
mediator complex subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (270 aa)
        score_image       0.571
TEX11
testis expressed 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity) (940 aa)
            score_image   0.562
FKBP6
FK506 binding protein 6, 36kDa (327 aa)
            score_image   0.480
MND1
meiotic nuclear divisions 1 homolog (S. cerevisiae); Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks (205 aa)
            score_image   0.472
SLX4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae); Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introduc [...] (1834 aa)
            score_image   0.434
ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration (1006 aa)
            score_image   0.407
SPATA8
spermatogenesis associated 8 (105 aa)
            score_image   0.407
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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