node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASAP2 | SPATA22 | ENSP00000281419 | ENSP00000380354 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration | spermatogenesis associated 22 | 0.407 |
FKBP6 | MEI1 | ENSP00000252037 | ENSP00000384115 | FK506 binding protein 6, 36kDa | meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity) | 0.457 |
FKBP6 | SPATA22 | ENSP00000252037 | ENSP00000380354 | FK506 binding protein 6, 36kDa | spermatogenesis associated 22 | 0.480 |
FKBP6 | TEX11 | ENSP00000252037 | ENSP00000340995 | FK506 binding protein 6, 36kDa | testis expressed 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity) | 0.435 |
MED4 | SPATA22 | ENSP00000258648 | ENSP00000380354 | mediator complex subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | spermatogenesis associated 22 | 0.571 |
MEI1 | FKBP6 | ENSP00000384115 | ENSP00000252037 | meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity) | FK506 binding protein 6, 36kDa | 0.457 |
MEI1 | SPATA22 | ENSP00000384115 | ENSP00000380354 | meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity) | spermatogenesis associated 22 | 0.603 |
MEI1 | TEX11 | ENSP00000384115 | ENSP00000340995 | meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity) | testis expressed 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity) | 0.413 |
MEIOB | SPATA22 | ENSP00000314484 | ENSP00000380354 | meiosis specific with OB domains; May be involved in early meiosis (By similarity) | spermatogenesis associated 22 | 0.634 |
MND1 | SPATA22 | ENSP00000240488 | ENSP00000380354 | meiotic nuclear divisions 1 homolog (S. cerevisiae); Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks | spermatogenesis associated 22 | 0.472 |
SLX4 | SPATA22 | ENSP00000294008 | ENSP00000380354 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae); Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introduc [...] | spermatogenesis associated 22 | 0.434 |
SPATA22 | ASAP2 | ENSP00000380354 | ENSP00000281419 | spermatogenesis associated 22 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration | 0.407 |
SPATA22 | FKBP6 | ENSP00000380354 | ENSP00000252037 | spermatogenesis associated 22 | FK506 binding protein 6, 36kDa | 0.480 |
SPATA22 | MED4 | ENSP00000380354 | ENSP00000258648 | spermatogenesis associated 22 | mediator complex subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.571 |
SPATA22 | MEI1 | ENSP00000380354 | ENSP00000384115 | spermatogenesis associated 22 | meiosis inhibitor 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity) | 0.603 |
SPATA22 | MEIOB | ENSP00000380354 | ENSP00000314484 | spermatogenesis associated 22 | meiosis specific with OB domains; May be involved in early meiosis (By similarity) | 0.634 |
SPATA22 | MND1 | ENSP00000380354 | ENSP00000240488 | spermatogenesis associated 22 | meiotic nuclear divisions 1 homolog (S. cerevisiae); Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks | 0.472 |
SPATA22 | SLX4 | ENSP00000380354 | ENSP00000294008 | spermatogenesis associated 22 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae); Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introduc [...] | 0.434 |
SPATA22 | SPATA8 | ENSP00000380354 | ENSP00000328149 | spermatogenesis associated 22 | spermatogenesis associated 8 | 0.407 |
SPATA22 | TEX11 | ENSP00000380354 | ENSP00000340995 | spermatogenesis associated 22 | testis expressed 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity) | 0.562 |