node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGAP3 | ANKRD28 | ENSP00000380413 | ENSP00000382379 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | ankyrin repeat domain 28; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation | 0.512 |
AGAP3 | ARL16 | ENSP00000380413 | ENSP00000380635 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | ADP-ribosylation factor-like 16 | 0.513 |
AGAP3 | ECD | ENSP00000380413 | ENSP00000401566 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | 0.700 |
AGAP3 | FAIM2 | ENSP00000380413 | ENSP00000321951 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development | 0.584 |
AGAP3 | FOS | ENSP00000380413 | ENSP00000306245 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell p [...] | 0.893 |
AGAP3 | RHOA | ENSP00000380413 | ENSP00000400175 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.894 |
AGAP3 | RHOB | ENSP00000380413 | ENSP00000272233 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | ras homolog family member B; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular develo [...] | 0.494 |
AGAP3 | RHOC | ENSP00000380413 | ENSP00000285735 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | ras homolog family member C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells | 0.494 |
AGAP3 | TMBIM1 | ENSP00000380413 | ENSP00000258412 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | transmembrane BAX inhibitor motif containing 1; Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling | 0.587 |
AGAP3 | UBC | ENSP00000380413 | ENSP00000344818 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | ubiquitin C | 0.643 |
ANKRD28 | AGAP3 | ENSP00000382379 | ENSP00000380413 | ankyrin repeat domain 28; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | 0.512 |
ANKRD28 | FAIM2 | ENSP00000382379 | ENSP00000321951 | ankyrin repeat domain 28; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation | Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development | 0.439 |
ANKRD28 | UBC | ENSP00000382379 | ENSP00000344818 | ankyrin repeat domain 28; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation | ubiquitin C | 0.824 |
ARL16 | AGAP3 | ENSP00000380635 | ENSP00000380413 | ADP-ribosylation factor-like 16 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | 0.513 |
ARL16 | UBC | ENSP00000380635 | ENSP00000344818 | ADP-ribosylation factor-like 16 | ubiquitin C | 0.424 |
ECD | AGAP3 | ENSP00000401566 | ENSP00000380413 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | 0.700 |
ECD | UBC | ENSP00000401566 | ENSP00000344818 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | ubiquitin C | 0.728 |
FAIM2 | AGAP3 | ENSP00000321951 | ENSP00000380413 | Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | 0.584 |
FAIM2 | ANKRD28 | ENSP00000321951 | ENSP00000382379 | Fas apoptotic inhibitory molecule 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development | ankyrin repeat domain 28; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation | 0.439 |
FOS | AGAP3 | ENSP00000306245 | ENSP00000380413 | FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell p [...] | ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway | 0.893 |