node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATAD2B | NPLOC4 | ENSP00000238789 | ENSP00000331487 | ATPase family, AAA domain containing 2B | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | 0.908 |
ATAD2B | NSFL1C | ENSP00000238789 | ENSP00000418529 | ATPase family, AAA domain containing 2B | NSFL1 (p97) cofactor (p47) | 0.749 |
ATAD2B | PLAA | ENSP00000238789 | ENSP00000380460 | ATPase family, AAA domain containing 2B | phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity) | 0.951 |
ATAD2B | UBC | ENSP00000238789 | ENSP00000344818 | ATPase family, AAA domain containing 2B | ubiquitin C | 0.581 |
ATAD2B | UBE4B | ENSP00000238789 | ENSP00000343001 | ATPase family, AAA domain containing 2B | ubiquitination factor E4B; Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 (By similarity) | 0.732 |
ATAD2B | UFD1L | ENSP00000238789 | ENSP00000263202 | ATPase family, AAA domain containing 2B | ubiquitin fusion degradation 1 like (yeast); Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures | 0.936 |
ATAD2B | YOD1 | ENSP00000238789 | ENSP00000326813 | ATPase family, AAA domain containing 2B | YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae); Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of both ’Lys-48’- and ’Lys-63’-linked [...] | 0.714 |
NPLOC4 | ATAD2B | ENSP00000331487 | ENSP00000238789 | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | ATPase family, AAA domain containing 2B | 0.908 |
NPLOC4 | NSFL1C | ENSP00000331487 | ENSP00000418529 | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | NSFL1 (p97) cofactor (p47) | 0.820 |
NPLOC4 | PLAA | ENSP00000331487 | ENSP00000380460 | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity) | 0.984 |
NPLOC4 | SPATA5 | ENSP00000331487 | ENSP00000274008 | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | spermatogenesis associated 5; May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity) | 0.955 |
NPLOC4 | UBC | ENSP00000331487 | ENSP00000344818 | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | ubiquitin C | 0.999 |
NPLOC4 | UBE4B | ENSP00000331487 | ENSP00000343001 | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | ubiquitination factor E4B; Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 (By similarity) | 0.987 |
NPLOC4 | UFD1L | ENSP00000331487 | ENSP00000263202 | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | ubiquitin fusion degradation 1 like (yeast); Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures | 0.999 |
NPLOC4 | VCP | ENSP00000331487 | ENSP00000351777 | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | valosin containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the e [...] | 0.999 |
NPLOC4 | YOD1 | ENSP00000331487 | ENSP00000326813 | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae); Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of both ’Lys-48’- and ’Lys-63’-linked [...] | 0.986 |
NSFL1C | ATAD2B | ENSP00000418529 | ENSP00000238789 | NSFL1 (p97) cofactor (p47) | ATPase family, AAA domain containing 2B | 0.749 |
NSFL1C | NPLOC4 | ENSP00000418529 | ENSP00000331487 | NSFL1 (p97) cofactor (p47) | nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) | 0.820 |
NSFL1C | PLAA | ENSP00000418529 | ENSP00000380460 | NSFL1 (p97) cofactor (p47) | phospholipase A2-activating protein; Involved in the maintenance of ubiquitin levels (By similarity) | 0.952 |
NSFL1C | SPATA5 | ENSP00000418529 | ENSP00000274008 | NSFL1 (p97) cofactor (p47) | spermatogenesis associated 5; May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity) | 0.864 |