HAGH protein (Homo sapiens) - STRING network view

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Score

HAGH

hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (308 aa)

Predicted Functional Partners:

GLO1

0.981

LDHD

0.908

GPA33

0.812

ASIC4

0.752

CES5A

0.751

PGP

0.617

CES1

0.590

MCEE

0.560

ADH5

0.540

ESD

0.537

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH5	CES1	ENSP00000296412	ENSP00000353720	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	carboxylesterase 1; Has no esterase activity (Probable)	0.582
ADH5	CES5A	ENSP00000296412	ENSP00000428864	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	0.745
ADH5	ESD	ENSP00000296412	ENSP00000367992	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	0.989
ADH5	HAGH	ENSP00000296412	ENSP00000380514	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	0.540
ASIC4	GPA33	ENSP00000326627	ENSP00000356842	acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity	glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling	0.816
ASIC4	HAGH	ENSP00000326627	ENSP00000380514	acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity	hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	0.752
CES1	ADH5	ENSP00000353720	ENSP00000296412	carboxylesterase 1; Has no esterase activity (Probable)	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	0.582
CES1	CES5A	ENSP00000353720	ENSP00000428864	carboxylesterase 1; Has no esterase activity (Probable)	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	0.908
CES1	ESD	ENSP00000353720	ENSP00000367992	carboxylesterase 1; Has no esterase activity (Probable)	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	0.645
CES1	HAGH	ENSP00000353720	ENSP00000380514	carboxylesterase 1; Has no esterase activity (Probable)	hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	0.590
CES5A	ADH5	ENSP00000428864	ENSP00000296412	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	0.745
CES5A	CES1	ENSP00000428864	ENSP00000353720	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	carboxylesterase 1; Has no esterase activity (Probable)	0.908
CES5A	ESD	ENSP00000428864	ENSP00000367992	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	0.754
CES5A	HAGH	ENSP00000428864	ENSP00000380514	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	0.751
ESD	ADH5	ENSP00000367992	ENSP00000296412	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	0.989
ESD	CES1	ENSP00000367992	ENSP00000353720	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	carboxylesterase 1; Has no esterase activity (Probable)	0.645
ESD	CES5A	ENSP00000367992	ENSP00000428864	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	0.754
ESD	GLO1	ENSP00000367992	ENSP00000362463	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	glyoxalase I; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B	0.597
ESD	HAGH	ENSP00000367992	ENSP00000380514	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	0.537
GLO1	ESD	ENSP00000362463	ENSP00000367992	glyoxalase I; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	0.597

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