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STRINGSTRING
SERPINA7 SERPINA7 LHFPL3 LHFPL3 LHFPL5 LHFPL5 TM4SF1 TM4SF1 ITGB1 ITGB1 TSPAN4 TSPAN4 TM4SF4 TM4SF4 ITGA3 ITGA3 UPK3A UPK3A LHFPL4 LHFPL4 UPK1B UPK1B
"TSPAN4" - tetraspanin 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSPAN4tetraspanin 4 (238 aa)    
Predicted Functional Partners:
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (798 aa)
         score_image   score_image   0.862
ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration (1066 aa)
         score_image   score_image   0.839
TM4SF4
transmembrane 4 L six family member 4; Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation (202 aa)
             score_image   0.817
LHFPL4
lipoma HMGIC fusion partner-like 4 (247 aa)
             score_image   0.759
LHFPL3
lipoma HMGIC fusion partner-like 3 (236 aa)
             score_image   0.749
LHFPL5
lipoma HMGIC fusion partner-like 5; May function in hair bundle morphogenesis (By similarity) (219 aa)
             score_image   0.686
TM4SF1
transmembrane 4 L six family member 1 (202 aa)
             score_image   0.680
UPK1B
uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity) (260 aa)
             score_image   0.667
UPK3A
uroplakin 3A; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity) (287 aa)
             score_image   0.661
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum (415 aa)
             score_image   0.651
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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