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STRINGSTRING
CD59 CD59 DFFA DFFA C6orf70 C6orf70 GPR39 GPR39 LYPD1 LYPD1 PLAUR PLAUR CDON CDON SLC7A14 SLC7A14 CPNE6 CPNE6 BAIAP2L1 BAIAP2L1 ARSJ ARSJ
"LYPD1" - LY6/PLAUR domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LYPD1LY6/PLAUR domain containing 1 (141 aa)    
Predicted Functional Partners:
GPR39
G protein-coupled receptor 39; Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity) (453 aa)
            score_image   0.838
CD59
CD59 molecule, complement regulatory protein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase (128 aa)
            score_image   0.680
PLAUR
plasminogen activator, urokinase receptor (335 aa)
            score_image   0.608
DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40) (331 aa)
            score_image   0.561
CPNE6
copine VI (neuronal); May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties. May have a role in synaptic plasticity (By similarity) (557 aa)
            score_image   0.537
SLC7A14
solute carrier family 7 (orphan transporter), member 14 (771 aa)
            score_image   0.507
CDON
Cdon homolog (mouse); Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity) (1264 aa)
            score_image   0.460
BAIAP2L1
BAI1-associated protein 2-like 1; May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (511 aa)
            score_image   0.439
ARSJ
arylsulfatase family, member J (599 aa)
            score_image   0.438
C6orf70
chromosome 6 open reading frame 70 (678 aa)
            score_image   0.408
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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