node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | RAB2B | ENSP00000253792 | ENSP00000380869 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | 0.621 |
ACLY | YARS | ENSP00000253792 | ENSP00000362576 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.657 |
AGFG1 | RAB2B | ENSP00000387282 | ENSP00000380869 | ArfGAP with FG repeats 1 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | 0.625 |
AGFG1 | RABL6 | ENSP00000387282 | ENSP00000360727 | ArfGAP with FG repeats 1 | RAB, member RAS oncogene family-like 6 | 0.610 |
FCF1 | MMACHC | ENSP00000344393 | ENSP00000383840 | FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity) | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 0.650 |
FCF1 | RAB2B | ENSP00000344393 | ENSP00000380869 | FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity) | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | 0.614 |
FGA | RAB2B | ENSP00000306361 | ENSP00000380869 | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | 0.607 |
ICA1 | RAB2B | ENSP00000379908 | ENSP00000380869 | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | 0.753 |
MMACHC | FCF1 | ENSP00000383840 | ENSP00000344393 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity) | 0.650 |
MMACHC | RAB2B | ENSP00000383840 | ENSP00000380869 | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | 0.640 |
RAB2B | ACLY | ENSP00000380869 | ENSP00000253792 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.621 |
RAB2B | AGFG1 | ENSP00000380869 | ENSP00000387282 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | ArfGAP with FG repeats 1 | 0.625 |
RAB2B | FCF1 | ENSP00000380869 | ENSP00000344393 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity) | 0.614 |
RAB2B | FGA | ENSP00000380869 | ENSP00000306361 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | fibrinogen alpha chain; Fibrinogen has a double function- yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation | 0.607 |
RAB2B | ICA1 | ENSP00000380869 | ENSP00000379908 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | islet cell autoantigen 1, 69kDa; May play a role in neurotransmitter secretion (By similarity) | 0.753 |
RAB2B | MMACHC | ENSP00000380869 | ENSP00000383840 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12) | 0.640 |
RAB2B | RABL6 | ENSP00000380869 | ENSP00000360727 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | RAB, member RAS oncogene family-like 6 | 0.608 |
RAB2B | TBC1D20 | ENSP00000380869 | ENSP00000346139 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | TBC1 domain family, member 20; May act as a GTPase-activating protein for Rab family protein(s) | 0.572 |
RAB2B | TIMM50 | ENSP00000380869 | ENSP00000318115 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body | 0.579 |
RAB2B | YARS | ENSP00000380869 | ENSP00000362576 | RAB2B, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (Potential) | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) | 0.746 |