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AVIL AVIL FABP9 FABP9 ZNF207 ZNF207 PRKRIP1 PRKRIP1 DGCR14 DGCR14 EIF2AK2 EIF2AK2 FRG1 FRG1 CCDC130 CCDC130 ZCCHC10 ZCCHC10 NKAP NKAP FRG1B FRG1B
"PRKRIP1" - PRKR interacting protein 1 (IL11 inducible) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Edges represent protein-protein associations
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
PRKRIP1PRKR interacting protein 1 (IL11 inducible); Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity) (184 aa)    
Predicted Functional Partners:
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 ( [...] (551 aa)
        score_image   score_image   0.659
ZCCHC10
zinc finger, CCHC domain containing 10 (170 aa)
      score_image     score_image   0.593
CCDC130
coiled-coil domain containing 130 (396 aa)
      score_image     score_image   0.578
FABP9
fatty acid binding protein 9, testis (132 aa)
            score_image   0.551
FRG1
FSHD region gene 1 (258 aa)
      score_image     score_image   0.537
DGCR14
DiGeorge syndrome critical region gene 14; May be involved in pre-mRNA splicing (476 aa)
            score_image   0.493
AVIL
advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis (819 aa)
            score_image   0.487
ZNF207
zinc finger protein 207 (494 aa)
            score_image   0.482
FRG1B
FSHD region gene 1 family, member B (182 aa)
      score_image     score_image   0.459
NKAP
NFKB activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (415 aa)
            score_image   0.452
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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