NSG1 protein (Homo sapiens) - STRING network view

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Score

NSG1

Neuron-specific protein family member 1 (185 aa)

Predicted Functional Partners:

STX18

0.833

EVC2

0.744

CRMP1

0.727

EVC

0.685

STX12

0.638

CHST11

0.622

CHST13

0.583

BSCL2

0.581

DPYSL5

0.531

MSX1

0.499

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BSCL2	NSG1	ENSP00000354032	ENSP00000381049	Berardinelli-Seip congenital lipodystrophy 2 (seipin); Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues	Neuron-specific protein family member 1	0.581
CHST11	NSG1	ENSP00000305725	ENSP00000381049	carbohydrate (chondroitin 4) sulfotransferase 11; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor	Neuron-specific protein family member 1	0.622
CHST13	NSG1	ENSP00000317404	ENSP00000381049	carbohydrate (chondroitin 4) sulfotransferase 13; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan	Neuron-specific protein family member 1	0.583
CRMP1	DPYSL5	ENSP00000321606	ENSP00000288699	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth	0.908
CRMP1	EVC	ENSP00000321606	ENSP00000264956	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity)	0.742
CRMP1	EVC2	ENSP00000321606	ENSP00000342144	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	Ellis van Creveld syndrome 2; Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development	0.659
CRMP1	MSX1	ENSP00000321606	ENSP00000372170	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity	0.403
CRMP1	NSG1	ENSP00000321606	ENSP00000381049	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	Neuron-specific protein family member 1	0.727
CRMP1	STX18	ENSP00000321606	ENSP00000305810	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	syntaxin 18; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER	0.667
DPYSL5	CRMP1	ENSP00000288699	ENSP00000321606	dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	0.908
DPYSL5	NSG1	ENSP00000288699	ENSP00000381049	dihydropyrimidinase-like 5; May have a function in neuronal differentiation and/or axon growth	Neuron-specific protein family member 1	0.531
EVC	CRMP1	ENSP00000264956	ENSP00000321606	Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity)	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	0.742
EVC	EVC2	ENSP00000264956	ENSP00000342144	Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity)	Ellis van Creveld syndrome 2; Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development	0.814
EVC	MSX1	ENSP00000264956	ENSP00000372170	Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity)	msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity	0.586
EVC	NSG1	ENSP00000264956	ENSP00000381049	Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity)	Neuron-specific protein family member 1	0.685
EVC	STX18	ENSP00000264956	ENSP00000305810	Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity)	syntaxin 18; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER	0.609
EVC2	CRMP1	ENSP00000342144	ENSP00000321606	Ellis van Creveld syndrome 2; Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development	collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration	0.659
EVC2	EVC	ENSP00000342144	ENSP00000264956	Ellis van Creveld syndrome 2; Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development	Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity)	0.814
EVC2	MSX1	ENSP00000342144	ENSP00000372170	Ellis van Creveld syndrome 2; Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development	msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity	0.452
EVC2	NSG1	ENSP00000342144	ENSP00000381049	Ellis van Creveld syndrome 2; Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development	Neuron-specific protein family member 1	0.744

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