splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSG00000258818
ribonuclease 4 precursor ; This RNase has marked specificity towards the 3’ side of uridine nucleotides (147 aa)
Predicted Functional Partners:
SPINT4
serine peptidase inhibitor, Kunitz type 4 (99 aa)
0.501
OR6X1
olfactory receptor, family 6, subfamily X, member 1; Odorant receptor (Potential) (312 aa)
0.482
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
Groups of genes that are frequently observed in each other's genomic neighborhood.
Experiments
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Fusion
Genes that are sometimes fused into single open reading frames.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Network Stats
Network Stats analysis is still ongoing, please wait ...
Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: