NPS protein (Homo sapiens) - STRING network view

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NPS

neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) (89 aa)

Predicted Functional Partners:

TAC1

0.994

VIP

0.990

POMC

0.989

CRH

0.987

CCK

0.986

NTS

0.986

OXT

0.986

GRP

0.986

TRH

0.980

AVP

0.980

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AVP	CCK	ENSP00000369647	ENSP00000335657	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	0.956
AVP	CRH	ENSP00000369647	ENSP00000276571	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	0.997
AVP	GRP	ENSP00000369647	ENSP00000256857	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	0.956
AVP	NPS	ENSP00000369647	ENSP00000381105	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.980
AVP	NTS	ENSP00000369647	ENSP00000256010	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle	0.956
AVP	OXT	ENSP00000369647	ENSP00000217386	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin	0.916
AVP	POMC	ENSP00000369647	ENSP00000264708	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.987
AVP	TAC1	ENSP00000369647	ENSP00000321106	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	tachykinin, precursor 1	0.960
AVP	TRH	ENSP00000369647	ENSP00000303452	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes	0.964
AVP	VIP	ENSP00000369647	ENSP00000356213	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder	0.963
CCK	AVP	ENSP00000335657	ENSP00000369647	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	0.956
CCK	CRH	ENSP00000335657	ENSP00000276571	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	0.725
CCK	GRP	ENSP00000335657	ENSP00000256857	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity)	0.989
CCK	NPS	ENSP00000335657	ENSP00000381105	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.986
CCK	NTS	ENSP00000335657	ENSP00000256010	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	neurotensin; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle	0.986
CCK	OXT	ENSP00000335657	ENSP00000217386	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin	0.995
CCK	POMC	ENSP00000335657	ENSP00000264708	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.757
CCK	TAC1	ENSP00000335657	ENSP00000321106	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	tachykinin, precursor 1	0.986
CCK	TRH	ENSP00000335657	ENSP00000303452	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes	0.970
CCK	VIP	ENSP00000335657	ENSP00000356213	cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion	vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder	0.824

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