Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
AIMP2 AIMP2 NME8 NME8 SLC24A4 SLC24A4 ZCWPW1 ZCWPW1 STAG3 STAG3 PPP1R35 PPP1R35 FAM180B FAM180B
"ZCWPW1" - zinc finger, CW type with PWWP domain 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZCWPW1zinc finger, CW type with PWWP domain 1 (648 aa)    
Predicted Functional Partners:
STAG3
stromal antigen 3; Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity) (1225 aa)
            score_image   0.510
PPP1R35
protein phosphatase 1, regulatory subunit 35; Inhibits PPP1CA phosphatase activity (253 aa)
            score_image   0.489
FAM180B
family with sequence similarity 180, member B (224 aa)
            score_image   0.422
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (622 aa)
            score_image   0.416
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor (320 aa)
            score_image   0.411
NME8
NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (588 aa)
            score_image   0.402
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (40%)