node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIMP2 | ZCWPW1 | ENSP00000223029 | ENSP00000381109 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor | zinc finger, CW type with PWWP domain 1 | 0.411 |
FAM180B | ZCWPW1 | ENSP00000349175 | ENSP00000381109 | family with sequence similarity 180, member B | zinc finger, CW type with PWWP domain 1 | 0.422 |
NME8 | SLC24A4 | ENSP00000199447 | ENSP00000431840 | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.406 |
NME8 | ZCWPW1 | ENSP00000199447 | ENSP00000381109 | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds | zinc finger, CW type with PWWP domain 1 | 0.402 |
PPP1R35 | ZCWPW1 | ENSP00000292330 | ENSP00000381109 | protein phosphatase 1, regulatory subunit 35; Inhibits PPP1CA phosphatase activity | zinc finger, CW type with PWWP domain 1 | 0.489 |
SLC24A4 | NME8 | ENSP00000431840 | ENSP00000199447 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds | 0.406 |
SLC24A4 | ZCWPW1 | ENSP00000431840 | ENSP00000381109 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | zinc finger, CW type with PWWP domain 1 | 0.416 |
STAG3 | ZCWPW1 | ENSP00000319318 | ENSP00000381109 | stromal antigen 3; Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity) | zinc finger, CW type with PWWP domain 1 | 0.510 |
ZCWPW1 | AIMP2 | ENSP00000381109 | ENSP00000223029 | zinc finger, CW type with PWWP domain 1 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor | 0.411 |
ZCWPW1 | FAM180B | ENSP00000381109 | ENSP00000349175 | zinc finger, CW type with PWWP domain 1 | family with sequence similarity 180, member B | 0.422 |
ZCWPW1 | NME8 | ENSP00000381109 | ENSP00000199447 | zinc finger, CW type with PWWP domain 1 | NME/NM23 family member 8; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds | 0.402 |
ZCWPW1 | PPP1R35 | ENSP00000381109 | ENSP00000292330 | zinc finger, CW type with PWWP domain 1 | protein phosphatase 1, regulatory subunit 35; Inhibits PPP1CA phosphatase activity | 0.489 |
ZCWPW1 | SLC24A4 | ENSP00000381109 | ENSP00000431840 | zinc finger, CW type with PWWP domain 1 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.416 |
ZCWPW1 | STAG3 | ENSP00000381109 | ENSP00000319318 | zinc finger, CW type with PWWP domain 1 | stromal antigen 3; Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity) | 0.510 |