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STRINGSTRING
GLYR1 GLYR1 NEURL2 NEURL2 CAPN12 CAPN12 MBLAC1 MBLAC1 ZNF676 ZNF676 NR1D1 NR1D1 FHAD1 FHAD1 WNK2 WNK2
"MBLAC1" - metallo-beta-lactamase domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
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[Homology]
Score
MBLAC1metallo-beta-lactamase domain containing 1 (266 aa)    
Predicted Functional Partners:
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1 (1453 aa)
            score_image   0.707
NR1D1
nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine (614 aa)
      score_image         0.673
ZNF676
zinc finger protein 676; May be involved in transcriptional regulation (588 aa)
            score_image   0.658
CAPN12
calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) (719 aa)
            score_image   0.572
WNK2
WNK lysine deficient protein kinase 2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulati [...] (2297 aa)
            score_image   0.507
NEURL2
neuralized homolog 2 (Drosophila); Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity) (285 aa)
            score_image   0.455
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis) (553 aa)
            score_image   0.421
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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