node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPN12 | FHAD1 | ENSP00000331636 | ENSP00000365167 | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.463 |
CAPN12 | MBLAC1 | ENSP00000331636 | ENSP00000381150 | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | metallo-beta-lactamase domain containing 1 | 0.572 |
CAPN12 | ZNF676 | ENSP00000331636 | ENSP00000380310 | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | zinc finger protein 676; May be involved in transcriptional regulation | 0.508 |
FHAD1 | CAPN12 | ENSP00000365167 | ENSP00000331636 | forkhead-associated (FHA) phosphopeptide binding domain 1 | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | 0.463 |
FHAD1 | MBLAC1 | ENSP00000365167 | ENSP00000381150 | forkhead-associated (FHA) phosphopeptide binding domain 1 | metallo-beta-lactamase domain containing 1 | 0.707 |
FHAD1 | WNK2 | ENSP00000365167 | ENSP00000297954 | forkhead-associated (FHA) phosphopeptide binding domain 1 | WNK lysine deficient protein kinase 2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulati [...] | 0.412 |
FHAD1 | ZNF676 | ENSP00000365167 | ENSP00000380310 | forkhead-associated (FHA) phosphopeptide binding domain 1 | zinc finger protein 676; May be involved in transcriptional regulation | 0.566 |
GLYR1 | MBLAC1 | ENSP00000322716 | ENSP00000381150 | glyoxylate reductase 1 homolog (Arabidopsis) | metallo-beta-lactamase domain containing 1 | 0.421 |
MBLAC1 | CAPN12 | ENSP00000381150 | ENSP00000331636 | metallo-beta-lactamase domain containing 1 | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | 0.572 |
MBLAC1 | FHAD1 | ENSP00000381150 | ENSP00000365167 | metallo-beta-lactamase domain containing 1 | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.707 |
MBLAC1 | GLYR1 | ENSP00000381150 | ENSP00000322716 | metallo-beta-lactamase domain containing 1 | glyoxylate reductase 1 homolog (Arabidopsis) | 0.421 |
MBLAC1 | NEURL2 | ENSP00000381150 | ENSP00000361596 | metallo-beta-lactamase domain containing 1 | neuralized homolog 2 (Drosophila); Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity) | 0.455 |
MBLAC1 | NR1D1 | ENSP00000381150 | ENSP00000246672 | metallo-beta-lactamase domain containing 1 | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | 0.673 |
MBLAC1 | WNK2 | ENSP00000381150 | ENSP00000297954 | metallo-beta-lactamase domain containing 1 | WNK lysine deficient protein kinase 2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulati [...] | 0.507 |
MBLAC1 | ZNF676 | ENSP00000381150 | ENSP00000380310 | metallo-beta-lactamase domain containing 1 | zinc finger protein 676; May be involved in transcriptional regulation | 0.658 |
NEURL2 | MBLAC1 | ENSP00000361596 | ENSP00000381150 | neuralized homolog 2 (Drosophila); Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity) | metallo-beta-lactamase domain containing 1 | 0.455 |
NR1D1 | MBLAC1 | ENSP00000246672 | ENSP00000381150 | nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine | metallo-beta-lactamase domain containing 1 | 0.673 |
WNK2 | FHAD1 | ENSP00000297954 | ENSP00000365167 | WNK lysine deficient protein kinase 2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulati [...] | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.412 |
WNK2 | MBLAC1 | ENSP00000297954 | ENSP00000381150 | WNK lysine deficient protein kinase 2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulati [...] | metallo-beta-lactamase domain containing 1 | 0.507 |
ZNF676 | CAPN12 | ENSP00000380310 | ENSP00000331636 | zinc finger protein 676; May be involved in transcriptional regulation | calpain 12; Calcium-regulated non-lysosomal thiol-protease (By similarity) | 0.508 |