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STRINGSTRING
WDR7 WDR7 PRR15 PRR15 RPAP2 RPAP2 MEIOB MEIOB KIAA1468 KIAA1468 UBC UBC HEATR6 HEATR6 HEATR4 HEATR4 STK36 STK36 RTDR1 RTDR1 TMCO7 TMCO7
KIAA1468 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KIAA1468KIAA1468 (1216 aa)    
Predicted Functional Partners:
HEATR4
HEAT repeat containing 4 (1026 aa)
            score_image   0.765
TMCO7
transmembrane and coiled-coil domains 7 (1094 aa)
            score_image   0.739
UBC
ubiquitin C (685 aa)
        score_image       0.721
HEATR6
HEAT repeat containing 6; Amplification-dependent oncogene (1181 aa)
            score_image   0.663
STK36
serine/threonine kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral [...] (1315 aa)
            score_image   0.644
RTDR1
rhabdoid tumor deletion region gene 1 (348 aa)
            score_image   0.637
WDR7
WD repeat domain 7 (1490 aa)
            score_image   0.623
MEIOB
meiosis specific with OB domains; May be involved in early meiosis (By similarity) (471 aa)
            score_image   0.612
PRR15
proline rich 15; May have a role in proliferation and/or differentiation (By similarity) (129 aa)
            score_image   0.608
RPAP2
RNA polymerase II associated protein 2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated ’Ser-7’ of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of ’Ser-5’ of the CTD, thereby promoting transcription of snRNA genes (612 aa)
            score_image   0.574
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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