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LPHN1 LPHN1 LPHN3 LPHN3 KCNJ1 KCNJ1 LPHN2 LPHN2 AGK AGK PPAPDC1A PPAPDC1A PPAPDC3 PPAPDC3 C10orf85 C10orf85 ACBD6 ACBD6 PLD2 PLD2 CERKL CERKL
"PPAPDC1A" - phosphatidic acid phosphatase type 2 domain containing 1A in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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PPAPDC1Aphosphatidic acid phosphatase type 2 domain containing 1A; Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol (271 aa)    
Predicted Functional Partners:
PLD2
phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) (933 aa)
          score_image score_image   0.906
C10orf85
chromosome 10 open reading frame 85 (128 aa)
            score_image   0.812
LPHN3
latrophilin 3 (1469 aa)
            score_image   0.662
LPHN2
latrophilin 2 (1403 aa)
            score_image   0.561
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1; In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by [...] (391 aa)
            score_image   0.549
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) (271 aa)
            score_image   0.516
LPHN1
latrophilin 1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis (By similarity) (1474 aa)
            score_image   0.420
ACBD6
acyl-CoA binding domain containing 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18-1-CoA, lower affinity for unsaturated C20-4-CoA, and very weak affinity for saturated C16-0- CoA. Does not bind fatty acids (282 aa)
            score_image   0.420
AGK
acylglycerol kinase; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (422 aa)
score_image       score_image   score_image   0.409
CERKL
ceramide kinase-like (558 aa)
score_image       score_image   score_image   0.409
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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