node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CREB1 | CRH | ENSP00000387699 | ENSP00000276571 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 0.912 |
CREB1 | CRHR1 | ENSP00000387699 | ENSP00000381333 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.890 |
CREB1 | KCNMA1 | ENSP00000387699 | ENSP00000385806 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 0.430 |
CREB1 | POMC | ENSP00000387699 | ENSP00000264708 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.568 |
CREB1 | YY1 | ENSP00000387699 | ENSP00000262238 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | YY1 transcription factor; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repre [...] | 0.903 |
CRH | CREB1 | ENSP00000276571 | ENSP00000387699 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | 0.912 |
CRH | CRHBP | ENSP00000276571 | ENSP00000274368 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | corticotropin releasing hormone binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy | 0.962 |
CRH | CRHR1 | ENSP00000276571 | ENSP00000381333 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.999 |
CRH | POMC | ENSP00000276571 | ENSP00000264708 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.998 |
CRH | UCN | ENSP00000276571 | ENSP00000296099 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | urocortin; Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta | 0.980 |
CRH | UCN2 | ENSP00000276571 | ENSP00000273610 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | urocortin 2; Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress | 0.813 |
CRHBP | CRH | ENSP00000274368 | ENSP00000276571 | corticotropin releasing hormone binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 0.962 |
CRHBP | CRHR1 | ENSP00000274368 | ENSP00000381333 | corticotropin releasing hormone binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.817 |
CRHBP | POMC | ENSP00000274368 | ENSP00000264708 | corticotropin releasing hormone binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.582 |
CRHBP | UCN | ENSP00000274368 | ENSP00000296099 | corticotropin releasing hormone binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy | urocortin; Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta | 0.974 |
CRHBP | UCN2 | ENSP00000274368 | ENSP00000273610 | corticotropin releasing hormone binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy | urocortin 2; Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress | 0.628 |
CRHR1 | CREB1 | ENSP00000381333 | ENSP00000387699 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | 0.890 |
CRHR1 | CRH | ENSP00000381333 | ENSP00000276571 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 0.999 |
CRHR1 | CRHBP | ENSP00000381333 | ENSP00000274368 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | corticotropin releasing hormone binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy | 0.817 |
CRHR1 | DLG1 | ENSP00000381333 | ENSP00000345731 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | discs, large homolog 1 (Drosophila) | 0.826 |