Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SLC2A11 | solute carrier family 2 (facilitated glucose transporter), member 11; Facilitative glucose transporter (503 aa) | ||||||||||||
Predicted Functional Partners:
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 | STYXL1 | serine/threonine/tyrosine interacting-like 1 (313 aa) |
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0.550 | ||||||||||
 | TOP2A | topoisomerase (DNA) II alpha 170kDa (1531 aa) |
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0.493 | ||||||||||
 | TOP2B | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (1621 aa) |
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0.493 | ||||||||||
 | MYH14 | myosin, heavy chain 14, non-muscle (2036 aa) |
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0.482 | ||||||||||
 | CELA3A | chymotrypsin-like elastase family, member 3A; Efficient protease with alanine specificity but only little elastolytic activity (270 aa) |
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0.480 | ||||||||||
 | CARK | FPGT-TNNI3K readthrough; May play a role in cardiac physiology (936 aa) |
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0.465 | ||||||||||
 | BHMT2 | betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor (363 aa) |
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0.462 | ||||||||||
 | SLC2A12 | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) (617 aa) |
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0.458 | ||||||||
 | TOE1 | target of EGR1, member 1 (nuclear); Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1 (510 aa) |
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0.459 | ||||||||||
 | NKAP | NFKB activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (415 aa) |
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0.451 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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