Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SPAG11B | sperm associated antigen 11B (133 aa) | ||||||||||||
Predicted Functional Partners:
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 | DEFB126 | defensin, beta 126; Has antibacterial activity (Potential) (111 aa) |
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0.709 | ||||||||||
 | DEFB103B | defensin, beta 103B; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed (67 aa) |
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0.706 | ||||||||||
 | DEFB103A | defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed (67 aa) |
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0.602 | ||||||||||
 | CXCL13 | chemokine (C-X-C motif) ligand 13; Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5 (109 aa) |
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0.589 | ||||||||||
 | DEFB136 | defensin, beta 136; Has antibacterial activity (Potential) (78 aa) |
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0.483 | ||||||||||
 | DEFB118 | defensin, beta 118; Has antibacterial activity (Potential) (123 aa) |
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0.483 | ||||||||||
 | DEFB124 | defensin, beta 124; Has antibacterial activity (Potential) (71 aa) |
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0.483 | ||||||||||
 | SRPK1 | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] (655 aa) |
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0.461 | ||||||||||
 | LCN6 | lipocalin 6; May play a role in male fertility (163 aa) |
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0.459 | ||||||||||
 | DEFB1 | defensin, beta 1; Has bactericidal activity (By similarity) (68 aa) |
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0.403 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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