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BDH2 BDH2 ACACB ACACB ACACA ACACA ILVBL ILVBL HMGCS1 HMGCS1 HMGCLL1 HMGCLL1 HACL1 HACL1 ACLY ACLY IDH3A IDH3A IDH3B IDH3B IDH3G IDH3G
"HMGCLL1" - 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues (370 aa)    
Predicted Functional Partners:
IDH3B
isocitrate dehydrogenase 3 (NAD+) beta (385 aa)
score_image     score_image score_image   score_image   0.809
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha (366 aa)
score_image     score_image score_image   score_image   0.809
IDH3G
isocitrate dehydrogenase 3 (NAD+) gamma (393 aa)
score_image     score_image score_image   score_image   0.809
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
      score_image score_image   score_image   0.774
ACACA
acetyl-CoA carboxylase alpha (2383 aa)
score_image           score_image   0.693
ACACB
acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
score_image           score_image   0.693
BDH2
3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) (245 aa)
            score_image   0.680
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase (520 aa)
            score_image   0.673
HACL1
2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde (578 aa)
score_image     score_image     score_image   0.658
ILVBL
ilvB (bacterial acetolactate synthase)-like (632 aa)
score_image     score_image     score_image   0.658
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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