| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC8 | MAEA | ENSP00000420333 | ENSP00000302830 | armadillo repeat containing 8 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.938 |
| ARMC8 | WDR26 | ENSP00000420333 | ENSP00000408108 | armadillo repeat containing 8 | WD repeat domain 26; May be involved in MAPK pathways | 0.859 |
| ARMC8 | YPEL3 | ENSP00000420333 | ENSP00000381821 | armadillo repeat containing 8 | yippee-like 3 (Drosophila); Involved in proliferation and apoptosis in myeloid precursor cells (By similarity) | 0.539 |
| CARHSP1 | COMMD1 | ENSP00000311847 | ENSP00000308236 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | 0.496 |
| CARHSP1 | STARD3 | ENSP00000311847 | ENSP00000337446 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.422 |
| CARHSP1 | YPEL3 | ENSP00000311847 | ENSP00000381821 | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | yippee-like 3 (Drosophila); Involved in proliferation and apoptosis in myeloid precursor cells (By similarity) | 0.541 |
| COMMD1 | CARHSP1 | ENSP00000308236 | ENSP00000311847 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | 0.496 |
| COMMD1 | STARD3 | ENSP00000308236 | ENSP00000337446 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | 0.501 |
| COMMD1 | YPEL3 | ENSP00000308236 | ENSP00000381821 | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | yippee-like 3 (Drosophila); Involved in proliferation and apoptosis in myeloid precursor cells (By similarity) | 0.609 |
| MAEA | ARMC8 | ENSP00000302830 | ENSP00000420333 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | armadillo repeat containing 8 | 0.938 |
| MAEA | WDR26 | ENSP00000302830 | ENSP00000408108 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | WD repeat domain 26; May be involved in MAPK pathways | 0.950 |
| MAEA | YPEL3 | ENSP00000302830 | ENSP00000381821 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | yippee-like 3 (Drosophila); Involved in proliferation and apoptosis in myeloid precursor cells (By similarity) | 0.640 |
| MTMR3 | YPEL3 | ENSP00000384651 | ENSP00000381821 | myotubularin related protein 3; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues | yippee-like 3 (Drosophila); Involved in proliferation and apoptosis in myeloid precursor cells (By similarity) | 0.553 |
| STARD3 | CARHSP1 | ENSP00000337446 | ENSP00000311847 | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | calcium regulated heat stable protein 1, 24kDa; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) | 0.422 |
| STARD3 | COMMD1 | ENSP00000337446 | ENSP00000308236 | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes | 0.501 |
| STARD3 | YPEL3 | ENSP00000337446 | ENSP00000381821 | StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain | yippee-like 3 (Drosophila); Involved in proliferation and apoptosis in myeloid precursor cells (By similarity) | 0.589 |
| WDR26 | ARMC8 | ENSP00000408108 | ENSP00000420333 | WD repeat domain 26; May be involved in MAPK pathways | armadillo repeat containing 8 | 0.859 |
| WDR26 | MAEA | ENSP00000408108 | ENSP00000302830 | WD repeat domain 26; May be involved in MAPK pathways | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.950 |
| WDR26 | YPEL3 | ENSP00000408108 | ENSP00000381821 | WD repeat domain 26; May be involved in MAPK pathways | yippee-like 3 (Drosophila); Involved in proliferation and apoptosis in myeloid precursor cells (By similarity) | 0.704 |
| YIPF5 | YPEL3 | ENSP00000274496 | ENSP00000381821 | Yip1 domain family, member 5; Plays a role in transport between endoplasmic reticulum and Golgi | yippee-like 3 (Drosophila); Involved in proliferation and apoptosis in myeloid precursor cells (By similarity) | 0.693 |
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