| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C4orf46 | MGARP | ENSP00000368503 | ENSP00000381928 | chromosome 4 open reading frame 46 | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | 0.457 |
| C4orf46 | TIGD2 | ENSP00000368503 | ENSP00000317170 | chromosome 4 open reading frame 46 | tigger transposable element derived 2 | 0.626 |
| LEP | MGARP | ENSP00000312652 | ENSP00000381928 | leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | 0.804 |
| MGARP | C4orf46 | ENSP00000381928 | ENSP00000368503 | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | chromosome 4 open reading frame 46 | 0.457 |
| MGARP | LEP | ENSP00000381928 | ENSP00000312652 | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass | 0.804 |
| MGARP | PATZ1 | ENSP00000381928 | ENSP00000266269 | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | POZ (BTB) and AT hook containing zinc finger 1; Transcriptional repressor | 0.485 |
| MGARP | RHOT1 | ENSP00000381928 | ENSP00000351132 | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | ras homolog family member T1; Mitochondrial GTPase involved in mitochondrial trafficking (By similarity) | 0.841 |
| MGARP | SP1 | ENSP00000381928 | ENSP00000329357 | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.803 |
| MGARP | TIGD2 | ENSP00000381928 | ENSP00000317170 | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | tigger transposable element derived 2 | 0.414 |
| MGARP | TRAK2 | ENSP00000381928 | ENSP00000328875 | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | trafficking protein, kinesin binding 2; May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR (By similarity) | 0.854 |
| PATZ1 | MGARP | ENSP00000266269 | ENSP00000381928 | POZ (BTB) and AT hook containing zinc finger 1; Transcriptional repressor | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | 0.485 |
| RHOT1 | MGARP | ENSP00000351132 | ENSP00000381928 | ras homolog family member T1; Mitochondrial GTPase involved in mitochondrial trafficking (By similarity) | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | 0.841 |
| RHOT1 | TRAK2 | ENSP00000351132 | ENSP00000328875 | ras homolog family member T1; Mitochondrial GTPase involved in mitochondrial trafficking (By similarity) | trafficking protein, kinesin binding 2; May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR (By similarity) | 0.867 |
| SP1 | MGARP | ENSP00000329357 | ENSP00000381928 | Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | 0.803 |
| TIGD2 | C4orf46 | ENSP00000317170 | ENSP00000368503 | tigger transposable element derived 2 | chromosome 4 open reading frame 46 | 0.626 |
| TIGD2 | MGARP | ENSP00000317170 | ENSP00000381928 | tigger transposable element derived 2 | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | 0.414 |
| TRAK2 | MGARP | ENSP00000328875 | ENSP00000381928 | trafficking protein, kinesin binding 2; May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR (By similarity) | mitochondria-localized glutamic acid-rich protein; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity) | 0.854 |
| TRAK2 | RHOT1 | ENSP00000328875 | ENSP00000351132 | trafficking protein, kinesin binding 2; May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR (By similarity) | ras homolog family member T1; Mitochondrial GTPase involved in mitochondrial trafficking (By similarity) | 0.867 |
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