node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRD2 | HLA-DQB1 | ENSP00000378702 | ENSP00000382034 | bromodomain containing 2 | major histocompatibility complex, class II, DQ beta 1 | 0.709 |
CD4 | CD8A | ENSP00000011653 | ENSP00000283635 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.997 |
CD4 | CIITA | ENSP00000011653 | ENSP00000316328 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | class II, major histocompatibility complex, transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter | 0.416 |
CD4 | HLA-DQA1 | ENSP00000011653 | ENSP00000339398 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | major histocompatibility complex, class II, DQ alpha 1 | 0.448 |
CD4 | HLA-DQB1 | ENSP00000011653 | ENSP00000382034 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | major histocompatibility complex, class II, DQ beta 1 | 0.863 |
CD4 | INS | ENSP00000011653 | ENSP00000250971 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.504 |
CD4 | TNFRSF25 | ENSP00000011653 | ENSP00000367013 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | tumor necrosis factor receptor superfamily, member 25 | 0.536 |
CD4 | TOR1A | ENSP00000011653 | ENSP00000345719 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.503 |
CD74 | CD8A | ENSP00000009530 | ENSP00000283635 | CD74 molecule, major histocompatibility complex, class II invariant chain | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | 0.412 |
CD74 | CIITA | ENSP00000009530 | ENSP00000316328 | CD74 molecule, major histocompatibility complex, class II invariant chain | class II, major histocompatibility complex, transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter | 0.472 |
CD74 | HLA-DQA1 | ENSP00000009530 | ENSP00000339398 | CD74 molecule, major histocompatibility complex, class II invariant chain | major histocompatibility complex, class II, DQ alpha 1 | 0.744 |
CD74 | HLA-DQB1 | ENSP00000009530 | ENSP00000382034 | CD74 molecule, major histocompatibility complex, class II invariant chain | major histocompatibility complex, class II, DQ beta 1 | 0.732 |
CD74 | HLA-DRB5 | ENSP00000009530 | ENSP00000364114 | CD74 molecule, major histocompatibility complex, class II invariant chain | major histocompatibility complex, class II, DR beta 5 | 0.921 |
CD8A | CD4 | ENSP00000283635 | ENSP00000011653 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.997 |
CD8A | CD74 | ENSP00000283635 | ENSP00000009530 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.412 |
CD8A | CIITA | ENSP00000283635 | ENSP00000316328 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | class II, major histocompatibility complex, transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter | 0.570 |
CD8A | HLA-DQB1 | ENSP00000283635 | ENSP00000382034 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | major histocompatibility complex, class II, DQ beta 1 | 0.710 |
CD8A | INS | ENSP00000283635 | ENSP00000250971 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.660 |
CD8A | TNFRSF25 | ENSP00000283635 | ENSP00000367013 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | tumor necrosis factor receptor superfamily, member 25 | 0.414 |
CD8A | TOR1A | ENSP00000283635 | ENSP00000345719 | CD8a molecule; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.418 |