node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | AIFM3 | ENSP00000253792 | ENSP00000382120 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.608 |
ACLY | DMGDH | ENSP00000253792 | ENSP00000255189 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | dimethylglycine dehydrogenase | 0.688 |
ACLY | DPYD | ENSP00000253792 | ENSP00000359211 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | dihydropyrimidine dehydrogenase | 0.940 |
ACLY | L2HGDH | ENSP00000253792 | ENSP00000267436 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | L-2-hydroxyglutarate dehydrogenase | 0.703 |
ACLY | TOP2A | ENSP00000253792 | ENSP00000411532 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | topoisomerase (DNA) II alpha 170kDa | 0.645 |
ACLY | UROD | ENSP00000253792 | ENSP00000246337 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III | 0.632 |
AIFM3 | ACLY | ENSP00000382120 | ENSP00000253792 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.608 |
AIFM3 | CISD1 | ENSP00000382120 | ENSP00000363041 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | CDGSH iron sulfur domain 1; Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions | 0.686 |
AIFM3 | CISD2 | ENSP00000382120 | ENSP00000273986 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | CDGSH iron sulfur domain 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy | 0.686 |
AIFM3 | DMGDH | ENSP00000382120 | ENSP00000255189 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | dimethylglycine dehydrogenase | 0.625 |
AIFM3 | DPYD | ENSP00000382120 | ENSP00000359211 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | dihydropyrimidine dehydrogenase | 0.597 |
AIFM3 | L2HGDH | ENSP00000382120 | ENSP00000267436 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | L-2-hydroxyglutarate dehydrogenase | 0.676 |
AIFM3 | SDR39U1 | ENSP00000382120 | ENSP00000382327 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | 0.585 |
AIFM3 | SPAG9 | ENSP00000382120 | ENSP00000262013 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | sperm associated antigen 9 | 0.593 |
AIFM3 | TOP2A | ENSP00000382120 | ENSP00000411532 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | topoisomerase (DNA) II alpha 170kDa | 0.575 |
AIFM3 | UROD | ENSP00000382120 | ENSP00000246337 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III | 0.598 |
CISD1 | AIFM3 | ENSP00000363041 | ENSP00000382120 | CDGSH iron sulfur domain 1; Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.686 |
CISD2 | AIFM3 | ENSP00000273986 | ENSP00000382120 | CDGSH iron sulfur domain 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.686 |
DMGDH | ACLY | ENSP00000255189 | ENSP00000253792 | dimethylglycine dehydrogenase | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.688 |
DMGDH | AIFM3 | ENSP00000255189 | ENSP00000382120 | dimethylglycine dehydrogenase | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.625 |