node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AK3 | MDGA2 | ENSP00000371230 | ENSP00000382178 | adenylate kinase 3; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP-AMP phosphotransferase and ITP-AMP phosphotransferase activities | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | 0.419 |
CNOT7 | MDGA2 | ENSP00000355279 | ENSP00000382178 | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | 0.420 |
HBS1L | MDGA2 | ENSP00000356811 | ENSP00000382178 | HBS1-like (S. cerevisiae) | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | 0.536 |
HBS1L | RNF144B | ENSP00000356811 | ENSP00000259939 | HBS1-like (S. cerevisiae) | ring finger protein 144B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se | 0.478 |
LIN7A | MDGA2 | ENSP00000447488 | ENSP00000382178 | lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | 0.499 |
LIN7A | MTUS2 | ENSP00000447488 | ENSP00000392057 | lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | microtubule associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip | 0.486 |
LIN7A | NPAS3 | ENSP00000447488 | ENSP00000348460 | lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | neuronal PAS domain protein 3; May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity) | 0.416 |
MDGA2 | AK3 | ENSP00000382178 | ENSP00000371230 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | adenylate kinase 3; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP-AMP phosphotransferase and ITP-AMP phosphotransferase activities | 0.419 |
MDGA2 | CNOT7 | ENSP00000382178 | ENSP00000355279 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | 0.420 |
MDGA2 | HBS1L | ENSP00000382178 | ENSP00000356811 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | HBS1-like (S. cerevisiae) | 0.536 |
MDGA2 | LIN7A | ENSP00000382178 | ENSP00000447488 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | 0.499 |
MDGA2 | MTUS2 | ENSP00000382178 | ENSP00000392057 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | microtubule associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip | 0.490 |
MDGA2 | NPAS3 | ENSP00000382178 | ENSP00000348460 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | neuronal PAS domain protein 3; May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity) | 0.468 |
MDGA2 | RNF144B | ENSP00000382178 | ENSP00000259939 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | ring finger protein 144B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se | 0.500 |
MDGA2 | SIGLEC14 | ENSP00000382178 | ENSP00000354090 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | sialic acid binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors | 0.963 |
MDGA2 | SLITRK3 | ENSP00000382178 | ENSP00000241274 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | SLIT and NTRK-like family, member 3; Suppresses neurite outgrowth (By similarity) | 0.475 |
MDGA2 | XYLT1 | ENSP00000382178 | ENSP00000261381 | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | xylosyltransferase I; Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes | 0.435 |
MTUS2 | LIN7A | ENSP00000392057 | ENSP00000447488 | microtubule associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip | lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | 0.486 |
MTUS2 | MDGA2 | ENSP00000392057 | ENSP00000382178 | microtubule associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip | MAM domain containing glycosylphosphatidylinositol anchor 2; May involved in cell-cell interactions (By similarity) | 0.490 |
MTUS2 | NPAS3 | ENSP00000392057 | ENSP00000348460 | microtubule associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip | neuronal PAS domain protein 3; May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity) | 0.448 |