node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRD1 | JMJD1C | ENSP00000216267 | ENSP00000382204 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | jumonji domain containing 1C | 0.745 |
BRD1 | KDM4B | ENSP00000216267 | ENSP00000159111 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | lysine (K)-specific demethylase 4B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Only able to demethylate trimethylated H3 ’Lys-9’, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate | 0.409 |
BRD1 | UBC | ENSP00000216267 | ENSP00000344818 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | ubiquitin C | 0.513 |
JMJD1C | BRD1 | ENSP00000382204 | ENSP00000216267 | jumonji domain containing 1C | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | 0.745 |
JMJD1C | KDM4A | ENSP00000382204 | ENSP00000361473 | jumonji domain containing 1C | lysine (K)-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively | 0.823 |
JMJD1C | KDM4B | ENSP00000382204 | ENSP00000159111 | jumonji domain containing 1C | lysine (K)-specific demethylase 4B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Only able to demethylate trimethylated H3 ’Lys-9’, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate | 0.874 |
JMJD1C | KDM4C | ENSP00000382204 | ENSP00000370710 | jumonji domain containing 1C | lysine (K)-specific demethylase 4C | 0.820 |
JMJD1C | KDM4D | ENSP00000382204 | ENSP00000334181 | jumonji domain containing 1C | lysine (K)-specific demethylase 4D; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Demethylates both di- and trimethylated H3 ’Lys- 9’ residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate | 0.766 |
JMJD1C | MDC1 | ENSP00000382204 | ENSP00000365588 | jumonji domain containing 1C | mediator of DNA-damage checkpoint 1 | 0.929 |
JMJD1C | REEP3 | ENSP00000382204 | ENSP00000362863 | jumonji domain containing 1C | receptor accessory protein 3; May enhance the cell surface expression of odorant receptors (By similarity) | 0.808 |
JMJD1C | RXRA | ENSP00000382204 | ENSP00000419692 | jumonji domain containing 1C | retinoid X receptor, alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response [...] | 0.695 |
JMJD1C | THRB | ENSP00000382204 | ENSP00000348827 | jumonji domain containing 1C | thyroid hormone receptor, beta; High affinity receptor for triiodothyronine | 0.720 |
JMJD1C | UBC | ENSP00000382204 | ENSP00000344818 | jumonji domain containing 1C | ubiquitin C | 0.684 |
KDM4A | JMJD1C | ENSP00000361473 | ENSP00000382204 | lysine (K)-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively | jumonji domain containing 1C | 0.823 |
KDM4A | KDM4C | ENSP00000361473 | ENSP00000370710 | lysine (K)-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively | lysine (K)-specific demethylase 4C | 0.619 |
KDM4A | UBC | ENSP00000361473 | ENSP00000344818 | lysine (K)-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively | ubiquitin C | 0.925 |
KDM4B | BRD1 | ENSP00000159111 | ENSP00000216267 | lysine (K)-specific demethylase 4B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Only able to demethylate trimethylated H3 ’Lys-9’, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | 0.409 |
KDM4B | JMJD1C | ENSP00000159111 | ENSP00000382204 | lysine (K)-specific demethylase 4B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Only able to demethylate trimethylated H3 ’Lys-9’, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate | jumonji domain containing 1C | 0.874 |
KDM4B | UBC | ENSP00000159111 | ENSP00000344818 | lysine (K)-specific demethylase 4B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Only able to demethylate trimethylated H3 ’Lys-9’, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate | ubiquitin C | 0.832 |
KDM4C | JMJD1C | ENSP00000370710 | ENSP00000382204 | lysine (K)-specific demethylase 4C | jumonji domain containing 1C | 0.820 |