node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMY2A | RBM12B | ENSP00000397582 | ENSP00000382239 | amylase, alpha 2A (pancreatic) | RNA binding motif protein 12B | 0.487 |
CEP192 | RBM12B | ENSP00000427550 | ENSP00000382239 | centrosomal protein 192kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication | RNA binding motif protein 12B | 0.570 |
MAP1LC3A | RBM12B | ENSP00000363970 | ENSP00000382239 | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | RNA binding motif protein 12B | 0.701 |
MYO5A | RBM12B | ENSP00000382177 | ENSP00000382239 | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | RNA binding motif protein 12B | 0.685 |
MYO5B | RBM12B | ENSP00000285039 | ENSP00000382239 | myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity) | RNA binding motif protein 12B | 0.685 |
MYO5C | RBM12B | ENSP00000261839 | ENSP00000382239 | myosin VC; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues | RNA binding motif protein 12B | 0.685 |
RBM12B | AMY2A | ENSP00000382239 | ENSP00000397582 | RNA binding motif protein 12B | amylase, alpha 2A (pancreatic) | 0.487 |
RBM12B | CEP192 | ENSP00000382239 | ENSP00000427550 | RNA binding motif protein 12B | centrosomal protein 192kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication | 0.570 |
RBM12B | MAP1LC3A | ENSP00000382239 | ENSP00000363970 | RNA binding motif protein 12B | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.701 |
RBM12B | MYO5A | ENSP00000382239 | ENSP00000382177 | RNA binding motif protein 12B | myosin VA (heavy chain 12, myoxin); Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation | 0.685 |
RBM12B | MYO5B | ENSP00000382239 | ENSP00000285039 | RNA binding motif protein 12B | myosin VB; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity) | 0.685 |
RBM12B | MYO5C | ENSP00000382239 | ENSP00000261839 | RNA binding motif protein 12B | myosin VC; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues | 0.685 |
RBM12B | RBM41 | ENSP00000382239 | ENSP00000361557 | RNA binding motif protein 12B | RNA binding motif protein 41; May bind RNA (Potential) | 0.548 |
RBM12B | SF3A1 | ENSP00000382239 | ENSP00000215793 | RNA binding motif protein 12B | splicing factor 3a, subunit 1, 120kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex | 0.644 |
RBM12B | SUMO2 | ENSP00000382239 | ENSP00000405965 | RNA binding motif protein 12B | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.521 |
RBM12B | THAP2 | ENSP00000382239 | ENSP00000310796 | RNA binding motif protein 12B | THAP domain containing, apoptosis associated protein 2 | 0.523 |
RBM41 | RBM12B | ENSP00000361557 | ENSP00000382239 | RNA binding motif protein 41; May bind RNA (Potential) | RNA binding motif protein 12B | 0.548 |
SF3A1 | RBM12B | ENSP00000215793 | ENSP00000382239 | splicing factor 3a, subunit 1, 120kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex | RNA binding motif protein 12B | 0.644 |
SF3A1 | SUMO2 | ENSP00000215793 | ENSP00000405965 | splicing factor 3a, subunit 1, 120kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.507 |
SUMO2 | RBM12B | ENSP00000405965 | ENSP00000382239 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | RNA binding motif protein 12B | 0.521 |