node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS10 | SDR39U1 | ENSP00000270328 | ENSP00000382327 | ADAM metallopeptidase with thrombospondin type 1 motif, 10; Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | 0.427 |
AIFM3 | SDR39U1 | ENSP00000382120 | ENSP00000382327 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | 0.585 |
AIFM3 | SLC20A1 | ENSP00000382120 | ENSP00000272542 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | solute carrier family 20 (phosphate transporter), member 1; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus [...] | 0.437 |
AIFM3 | SLC20A2 | ENSP00000382120 | ENSP00000340465 | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | solute carrier family 20 (phosphate transporter), member 2; Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Fun [...] | 0.437 |
CTSG | SDR39U1 | ENSP00000216336 | ENSP00000382327 | cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | 0.485 |
KHNYN | SDR39U1 | ENSP00000251343 | ENSP00000382327 | KH and NYN domain containing | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | 0.441 |
KHNYN | UBC | ENSP00000251343 | ENSP00000344818 | KH and NYN domain containing | ubiquitin C | 0.795 |
SDR39U1 | ADAMTS10 | ENSP00000382327 | ENSP00000270328 | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | ADAM metallopeptidase with thrombospondin type 1 motif, 10; Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues | 0.427 |
SDR39U1 | AIFM3 | ENSP00000382327 | ENSP00000382120 | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.585 |
SDR39U1 | CTSG | ENSP00000382327 | ENSP00000216336 | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride | 0.485 |
SDR39U1 | KHNYN | ENSP00000382327 | ENSP00000251343 | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | KH and NYN domain containing | 0.441 |
SDR39U1 | SLC20A1 | ENSP00000382327 | ENSP00000272542 | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | solute carrier family 20 (phosphate transporter), member 1; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus [...] | 0.435 |
SDR39U1 | SLC20A2 | ENSP00000382327 | ENSP00000340465 | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | solute carrier family 20 (phosphate transporter), member 2; Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Fun [...] | 0.435 |
SDR39U1 | TUBGCP6 | ENSP00000382327 | ENSP00000248846 | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | tubulin, gamma complex associated protein 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome | 0.417 |
SDR39U1 | UBC | ENSP00000382327 | ENSP00000344818 | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | ubiquitin C | 0.483 |
SDR39U1 | WDR83OS | ENSP00000382327 | ENSP00000468969 | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | WD repeat domain 83 opposite strand | 0.446 |
SDR39U1 | ZNF706 | ENSP00000382327 | ENSP00000311768 | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | zinc finger protein 706 | 0.520 |
SLC20A1 | AIFM3 | ENSP00000272542 | ENSP00000382120 | solute carrier family 20 (phosphate transporter), member 1; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus [...] | apoptosis-inducing factor, mitochondrion-associated, 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.437 |
SLC20A1 | SDR39U1 | ENSP00000272542 | ENSP00000382327 | solute carrier family 20 (phosphate transporter), member 1; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus [...] | short chain dehydrogenase/reductase family 39U, member 1; Putative NADP-dependent oxidoreductase | 0.435 |
SLC20A1 | UBC | ENSP00000272542 | ENSP00000344818 | solute carrier family 20 (phosphate transporter), member 1; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus [...] | ubiquitin C | 0.944 |