SRL protein (Homo sapiens) - STRING network view

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Score

SRL

sarcalumenin; May be involved in the regulation of calcium transport (473 aa)

Predicted Functional Partners:

RAD51

0.891

ATP2A1

0.759

SRRM1

0.741

NUMBL

0.726

NUMB

0.723

TNS1

0.723

GALK1

0.700

TNNT3

0.699

ATP2A2

0.694

UTP15

0.622

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP2A1	SRL	ENSP00000349595	ENSP00000382518	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction	sarcalumenin; May be involved in the regulation of calcium transport	0.759
ATP2A1	TNNT3	ENSP00000349595	ENSP00000278317	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction	troponin T type 3 (skeletal, fast)	0.699
ATP2A2	SRL	ENSP00000440045	ENSP00000382518	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle	sarcalumenin; May be involved in the regulation of calcium transport	0.694
ATP2A2	TNNT3	ENSP00000440045	ENSP00000278317	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle	troponin T type 3 (skeletal, fast)	0.473
GALK1	NUMB	ENSP00000225614	ENSP00000347169	galactokinase 1; Major enzyme for galactose metabolism	numb homolog (Drosophila)	0.503
GALK1	RAD51	ENSP00000225614	ENSP00000372088	galactokinase 1; Major enzyme for galactose metabolism	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	0.874
GALK1	SRL	ENSP00000225614	ENSP00000382518	galactokinase 1; Major enzyme for galactose metabolism	sarcalumenin; May be involved in the regulation of calcium transport	0.700
GALK1	TNS1	ENSP00000225614	ENSP00000171887	galactokinase 1; Major enzyme for galactose metabolism	tensin 1; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton	0.568
NUMB	GALK1	ENSP00000347169	ENSP00000225614	numb homolog (Drosophila)	galactokinase 1; Major enzyme for galactose metabolism	0.503
NUMB	RAD51	ENSP00000347169	ENSP00000372088	numb homolog (Drosophila)	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	0.638
NUMB	SRL	ENSP00000347169	ENSP00000382518	numb homolog (Drosophila)	sarcalumenin; May be involved in the regulation of calcium transport	0.723
NUMB	TNS1	ENSP00000347169	ENSP00000171887	numb homolog (Drosophila)	tensin 1; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton	0.621
NUMBL	SRL	ENSP00000252891	ENSP00000382518	numb homolog (Drosophila)-like; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of [...]	sarcalumenin; May be involved in the regulation of calcium transport	0.726
RAD51	GALK1	ENSP00000372088	ENSP00000225614	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	galactokinase 1; Major enzyme for galactose metabolism	0.874
RAD51	NUMB	ENSP00000372088	ENSP00000347169	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	numb homolog (Drosophila)	0.638
RAD51	SRL	ENSP00000372088	ENSP00000382518	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	sarcalumenin; May be involved in the regulation of calcium transport	0.891
RAD51	TNS1	ENSP00000372088	ENSP00000171887	RAD51 homolog (S. cerevisiae); Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3	tensin 1; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton	0.712
SRL	ATP2A1	ENSP00000382518	ENSP00000349595	sarcalumenin; May be involved in the regulation of calcium transport	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction	0.759
SRL	ATP2A2	ENSP00000382518	ENSP00000440045	sarcalumenin; May be involved in the regulation of calcium transport	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle	0.694
SRL	GALK1	ENSP00000382518	ENSP00000225614	sarcalumenin; May be involved in the regulation of calcium transport	galactokinase 1; Major enzyme for galactose metabolism	0.700

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