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SIPA1L1 SIPA1L1 SPAG16 SPAG16 MFAP1 MFAP1 PPTC7 PPTC7 TSSK2 TSSK2 TSKU TSKU PPM1L PPM1L TSKS TSKS LRGUK LRGUK PHLPP2 PHLPP2 PHLPP1 PHLPP1
"TSSK2" - testis-specific serine kinase 2 in Homo sapiens
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TSSK2testis-specific serine kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body (358 aa)    
Predicted Functional Partners:
TSKS
testis-specific serine kinase substrate; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development (592 aa)
        score_image   score_image   0.994
SPAG16
sperm associated antigen 16; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity) (631 aa)
            score_image   0.865
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] (1323 aa)
score_image       score_image   score_image   0.788
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...] (1717 aa)
score_image       score_image   score_image   0.788
TSKU
tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) (353 aa)
        score_image   score_image   0.694
LRGUK
leucine-rich repeats and guanylate kinase domain containing (825 aa)
score_image       score_image   score_image   0.688
MFAP1
microfibrillar-associated protein 1; Component of the elastin-associated microfibrils (439 aa)
            score_image   0.668
SIPA1L1
signal-induced proliferation-associated 1 like 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity) (1804 aa)
        score_image   score_image   0.662
PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae) (304 aa)
score_image     score_image score_image   score_image   0.661
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6 (360 aa)
score_image       score_image   score_image   0.659
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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