| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCNE1 | FBXW7 | ENSP00000262643 | ENSP00000281708 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 | 0.999 |
| CCNE1 | UBC | ENSP00000262643 | ENSP00000344818 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | ubiquitin C | 0.999 |
| CCNE1 | UBE2QL1 | ENSP00000262643 | ENSP00000382713 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | ubiquitin-conjugating enzyme E2Q family-like 1; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential) | 0.812 |
| FBXW7 | CCNE1 | ENSP00000281708 | ENSP00000262643 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | 0.999 |
| FBXW7 | MED10 | ENSP00000281708 | ENSP00000255764 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 | mediator complex subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.469 |
| FBXW7 | UBC | ENSP00000281708 | ENSP00000344818 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 | ubiquitin C | 0.838 |
| FBXW7 | UBE2QL1 | ENSP00000281708 | ENSP00000382713 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 | ubiquitin-conjugating enzyme E2Q family-like 1; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential) | 0.917 |
| KIAA0947 | UBE2QL1 | ENSP00000296564 | ENSP00000382713 | KIAA0947 | ubiquitin-conjugating enzyme E2Q family-like 1; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential) | 0.509 |
| KLHL15 | UBC | ENSP00000332791 | ENSP00000344818 | kelch-like 15 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | ubiquitin C | 0.498 |
| KLHL15 | UBE2D4 | ENSP00000332791 | ENSP00000222402 | kelch-like 15 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | ubiquitin-conjugating enzyme E2D 4 (putative); Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer ’Lys-11’ and ’Lys-48’-linked polyubiquitination | 0.483 |
| KLHL15 | UBE2QL1 | ENSP00000332791 | ENSP00000382713 | kelch-like 15 (Drosophila); Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins | ubiquitin-conjugating enzyme E2Q family-like 1; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential) | 0.596 |
| MED10 | FBXW7 | ENSP00000255764 | ENSP00000281708 | mediator complex subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 | 0.469 |
| MED10 | UBC | ENSP00000255764 | ENSP00000344818 | mediator complex subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | ubiquitin C | 0.635 |
| MED10 | UBE2QL1 | ENSP00000255764 | ENSP00000382713 | mediator complex subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | ubiquitin-conjugating enzyme E2Q family-like 1; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential) | 0.526 |
| NPRL2 | UBC | ENSP00000232501 | ENSP00000344818 | nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs | ubiquitin C | 0.709 |
| NPRL2 | UBE2QL1 | ENSP00000232501 | ENSP00000382713 | nitrogen permease regulator-like 2 (S. cerevisiae); Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs | ubiquitin-conjugating enzyme E2Q family-like 1; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential) | 0.457 |
| RRP15 | UBC | ENSP00000355899 | ENSP00000344818 | ribosomal RNA processing 15 homolog (S. cerevisiae) | ubiquitin C | 0.721 |
| RRP15 | UBE2QL1 | ENSP00000355899 | ENSP00000382713 | ribosomal RNA processing 15 homolog (S. cerevisiae) | ubiquitin-conjugating enzyme E2Q family-like 1; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential) | 0.640 |
| UBC | CCNE1 | ENSP00000344818 | ENSP00000262643 | ubiquitin C | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | 0.999 |
| UBC | FBXW7 | ENSP00000344818 | ENSP00000281708 | ubiquitin C | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 | 0.838 |
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