| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIPL1 | CRB1 | ENSP00000370521 | ENSP00000356370 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | crumbs homolog 1 (Drosophila) | 0.824 |
| AIPL1 | GUCY2D | ENSP00000370521 | ENSP00000254854 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | 0.870 |
| AIPL1 | LCA5 | ENSP00000370521 | ENSP00000358861 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | Leber congenital amaurosis 5; Might be involved in minus end-directed microtubule transport | 0.810 |
| AIPL1 | RPE65 | ENSP00000370521 | ENSP00000262340 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | retinal pigment epithelium-specific protein 65kDa; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of th [...] | 0.815 |
| AIPL1 | RPGR | ENSP00000370521 | ENSP00000367766 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | retinitis pigmentosa GTPase regulator | 0.586 |
| AIPL1 | RPGRIP1 | ENSP00000370521 | ENSP00000382895 | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | retinitis pigmentosa GTPase regulator interacting protein 1; Essential for RPGR function and is also required for normal disk morphogenesis (By similarity) | 0.722 |
| CC2D2A | NPHP4 | ENSP00000398391 | ENSP00000367398 | coiled-coil and C2 domain containing 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity) | nephronophthisis 4; Involved in the organization of apical junctions in kidney cells together with NPHP1 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity) | 0.581 |
| CC2D2A | RPGRIP1 | ENSP00000398391 | ENSP00000382895 | coiled-coil and C2 domain containing 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity) | retinitis pigmentosa GTPase regulator interacting protein 1; Essential for RPGR function and is also required for normal disk morphogenesis (By similarity) | 0.644 |
| CC2D2A | TMEM67 | ENSP00000398391 | ENSP00000389998 | coiled-coil and C2 domain containing 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity) | transmembrane protein 67; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC) | 0.953 |
| CRB1 | AIPL1 | ENSP00000356370 | ENSP00000370521 | crumbs homolog 1 (Drosophila) | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | 0.824 |
| CRB1 | GUCY2D | ENSP00000356370 | ENSP00000254854 | crumbs homolog 1 (Drosophila) | guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | 0.757 |
| CRB1 | LCA5 | ENSP00000356370 | ENSP00000358861 | crumbs homolog 1 (Drosophila) | Leber congenital amaurosis 5; Might be involved in minus end-directed microtubule transport | 0.725 |
| CRB1 | RPE65 | ENSP00000356370 | ENSP00000262340 | crumbs homolog 1 (Drosophila) | retinal pigment epithelium-specific protein 65kDa; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of th [...] | 0.810 |
| CRB1 | RPGR | ENSP00000356370 | ENSP00000367766 | crumbs homolog 1 (Drosophila) | retinitis pigmentosa GTPase regulator | 0.597 |
| CRB1 | RPGRIP1 | ENSP00000356370 | ENSP00000382895 | crumbs homolog 1 (Drosophila) | retinitis pigmentosa GTPase regulator interacting protein 1; Essential for RPGR function and is also required for normal disk morphogenesis (By similarity) | 0.623 |
| GUCY2D | AIPL1 | ENSP00000254854 | ENSP00000370521 | guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | aryl hydrocarbon receptor interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization | 0.870 |
| GUCY2D | CRB1 | ENSP00000254854 | ENSP00000356370 | guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | crumbs homolog 1 (Drosophila) | 0.757 |
| GUCY2D | LCA5 | ENSP00000254854 | ENSP00000358861 | guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | Leber congenital amaurosis 5; Might be involved in minus end-directed microtubule transport | 0.720 |
| GUCY2D | RPE65 | ENSP00000254854 | ENSP00000262340 | guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | retinal pigment epithelium-specific protein 65kDa; Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis- retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of th [...] | 0.811 |
| GUCY2D | RPGR | ENSP00000254854 | ENSP00000367766 | guanylate cyclase 2D, membrane (retina-specific); Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction | retinitis pigmentosa GTPase regulator | 0.590 |
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