| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARGLU1 | CHERP | ENSP00000383059 | ENSP00000439856 | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | 0.702 |
| ARGLU1 | MED1 | ENSP00000383059 | ENSP00000300651 | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.810 |
| ARGLU1 | PRMT5 | ENSP00000383059 | ENSP00000319169 | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | protein arginine methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of [...] | 0.705 |
| ARGLU1 | SF3A2 | ENSP00000383059 | ENSP00000221494 | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex | 0.895 |
| ARGLU1 | SRA1 | ENSP00000383059 | ENSP00000337513 | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | steroid receptor RNA activator 1; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis | 0.702 |
| ARGLU1 | SRPK1 | ENSP00000383059 | ENSP00000362931 | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.461 |
| ARGLU1 | SRPK2 | ENSP00000383059 | ENSP00000377262 | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.845 |
| ARGLU1 | TMA16 | ENSP00000383059 | ENSP00000351380 | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | translation machinery associated 16 homolog (S. cerevisiae) | 0.473 |
| ARGLU1 | UBC | ENSP00000383059 | ENSP00000344818 | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | ubiquitin C | 0.483 |
| ARGLU1 | ZCCHC10 | ENSP00000383059 | ENSP00000324274 | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | zinc finger, CCHC domain containing 10 | 0.743 |
| CHERP | ARGLU1 | ENSP00000439856 | ENSP00000383059 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | 0.702 |
| CHERP | SF3A2 | ENSP00000439856 | ENSP00000221494 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex | 0.996 |
| CHERP | SRPK1 | ENSP00000439856 | ENSP00000362931 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] | 0.461 |
| CHERP | SRPK2 | ENSP00000439856 | ENSP00000377262 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.461 |
| CHERP | UBC | ENSP00000439856 | ENSP00000344818 | calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation | ubiquitin C | 0.893 |
| MED1 | ARGLU1 | ENSP00000300651 | ENSP00000383059 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | 0.810 |
| MED1 | SRA1 | ENSP00000300651 | ENSP00000337513 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | steroid receptor RNA activator 1; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis | 0.902 |
| MED1 | UBC | ENSP00000300651 | ENSP00000344818 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | ubiquitin C | 0.483 |
| PRMT5 | ARGLU1 | ENSP00000319169 | ENSP00000383059 | protein arginine methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of [...] | arginine and glutamate rich 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 | 0.705 |
| PRMT5 | UBC | ENSP00000319169 | ENSP00000344818 | protein arginine methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of [...] | ubiquitin C | 0.944 |
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