Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SLITRK6 | SLIT and NTRK-like family, member 6; Suppresses neurite outgrowth (By similarity) (841 aa) | ||||||||||||
Predicted Functional Partners:
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 | LRRN3 | leucine rich repeat neuronal 3 (708 aa) |
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0.709 | ||||||||||
 | LRRC20 | leucine rich repeat containing 20 (184 aa) |
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0.612 | ||||||||||
 | NTRK1 | neurotrophic tyrosine kinase, receptor, type 1 (796 aa) |
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0.563 | ||||||||||
 | PRAMEF12 | PRAME family member 12 (483 aa) |
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0.502 | ||||||||||
 | SCGN | secretagogin, EF-hand calcium binding protein (276 aa) |
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0.489 | ||||||||||
 | SMPD3 | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II); Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (655 aa) |
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0.472 | ||||||||||
 | OR6T1 | olfactory receptor, family 6, subfamily T, member 1; Odorant receptor (Potential) (323 aa) |
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0.470 | ||||||||||
 | CST9L | cystatin 9-like (147 aa) |
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0.459 | ||||||||||
 | ENSG00000263020 | Lymphocyte antigen 6 complex, locus G5B (228 aa) |
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0.457 | ||||||||||
 | CSNK2B | casein kinase 2, beta polypeptide (215 aa) |
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0.457 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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