node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCLK1 | MAB21L1 | ENSP00000255448 | ENSP00000369251 | doublecortin-like kinase 1; Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system | mab-21-like 1 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | 0.751 |
DCLK1 | NBEA | ENSP00000255448 | ENSP00000383295 | doublecortin-like kinase 1; Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | 0.754 |
DCLK1 | SMAD9 | ENSP00000255448 | ENSP00000369154 | doublecortin-like kinase 1; Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system | SMAD family member 9; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD) | 0.561 |
DLG2 | NBEA | ENSP00000365272 | ENSP00000383295 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | 0.566 |
DLG3 | NBEA | ENSP00000363480 | ENSP00000383295 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | 0.794 |
DLG3 | UBC | ENSP00000363480 | ENSP00000344818 | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | ubiquitin C | 0.759 |
MAB21L1 | DCLK1 | ENSP00000369251 | ENSP00000255448 | mab-21-like 1 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | doublecortin-like kinase 1; Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system | 0.751 |
MAB21L1 | NBEA | ENSP00000369251 | ENSP00000383295 | mab-21-like 1 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | 0.811 |
MAB21L1 | SMAD9 | ENSP00000369251 | ENSP00000369154 | mab-21-like 1 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | SMAD family member 9; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD) | 0.655 |
NBEA | DCLK1 | ENSP00000383295 | ENSP00000255448 | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | doublecortin-like kinase 1; Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system | 0.754 |
NBEA | DLG2 | ENSP00000383295 | ENSP00000365272 | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | 0.566 |
NBEA | DLG3 | ENSP00000383295 | ENSP00000363480 | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling | 0.794 |
NBEA | MAB21L1 | ENSP00000383295 | ENSP00000369251 | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | mab-21-like 1 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | 0.811 |
NBEA | PRKAR2A | ENSP00000383295 | ENSP00000265563 | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.624 |
NBEA | PRKAR2B | ENSP00000383295 | ENSP00000265717 | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.624 |
NBEA | RAB39B | ENSP00000383295 | ENSP00000358466 | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | RAB39B, member RAS oncogene family; May be involved in vesicular trafficking. Plays a role in synapse formation (By similarity) | 0.552 |
NBEA | SCAMP5 | ENSP00000383295 | ENSP00000355387 | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | secretory carrier membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway | 0.714 |
NBEA | SMAD9 | ENSP00000383295 | ENSP00000369154 | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | SMAD family member 9; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD) | 0.662 |
NBEA | UBC | ENSP00000383295 | ENSP00000344818 | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | ubiquitin C | 0.752 |
PRKAR2A | NBEA | ENSP00000265563 | ENSP00000383295 | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity) | 0.624 |