TXNRD2 protein (Homo sapiens) - STRING network view

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TXNRD2

thioredoxin reductase 2 (524 aa)

Predicted Functional Partners:

TXN2

0.983

TXN

0.947

SEPHS2

0.946

SEPHS1

0.921

NCOR1

0.921

CCBL1

0.918

CCBL2

0.918

CTH

0.911

SCLY

0.902

TRIP6

0.877

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCBL1	CTH	ENSP00000302227	ENSP00000359976	cysteine conjugate-beta lyase, cytoplasmic; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond	cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...]	0.936
CCBL1	TXNRD2	ENSP00000302227	ENSP00000383365	cysteine conjugate-beta lyase, cytoplasmic; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond	thioredoxin reductase 2	0.918
CCBL2	CTH	ENSP00000260508	ENSP00000359976	cysteine conjugate-beta lyase 2	cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...]	0.921
CCBL2	TXNRD2	ENSP00000260508	ENSP00000383365	cysteine conjugate-beta lyase 2	thioredoxin reductase 2	0.918
CTH	CCBL1	ENSP00000359976	ENSP00000302227	cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...]	cysteine conjugate-beta lyase, cytoplasmic; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond	0.936
CTH	CCBL2	ENSP00000359976	ENSP00000260508	cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...]	cysteine conjugate-beta lyase 2	0.921
CTH	TXNRD2	ENSP00000359976	ENSP00000383365	cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...]	thioredoxin reductase 2	0.911
NCOR1	TXNRD2	ENSP00000268712	ENSP00000383365	nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors	thioredoxin reductase 2	0.921
SCLY	SEPHS1	ENSP00000254663	ENSP00000367893	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	0.938
SCLY	SEPHS2	ENSP00000254663	ENSP00000426234	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP	0.929
SCLY	TXNRD2	ENSP00000254663	ENSP00000383365	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	thioredoxin reductase 2	0.902
SEPHS1	SCLY	ENSP00000367893	ENSP00000254663	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	0.938
SEPHS1	TXNRD2	ENSP00000367893	ENSP00000383365	selenophosphate synthetase 1; Synthesizes selenophosphate from selenide and ATP	thioredoxin reductase 2	0.921
SEPHS2	SCLY	ENSP00000426234	ENSP00000254663	selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP	selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium (By similarity)	0.929
SEPHS2	TXNRD2	ENSP00000426234	ENSP00000383365	selenophosphate synthetase 2; Synthesizes selenophosphate from selenide and ATP	thioredoxin reductase 2	0.946
TRIP6	TXNRD2	ENSP00000200457	ENSP00000383365	thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor	thioredoxin reductase 2	0.877
TXN	TXNRD2	ENSP00000363641	ENSP00000383365	thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...]	thioredoxin reductase 2	0.947
TXN2	TXNRD2	ENSP00000216185	ENSP00000383365	thioredoxin 2; Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity	thioredoxin reductase 2	0.983
TXNRD2	CCBL1	ENSP00000383365	ENSP00000302227	thioredoxin reductase 2	cysteine conjugate-beta lyase, cytoplasmic; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond	0.918
TXNRD2	CCBL2	ENSP00000383365	ENSP00000260508	thioredoxin reductase 2	cysteine conjugate-beta lyase 2	0.918

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