Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | KLHDC7A | kelch domain containing 7A (777 aa) | ||||||||||||
Predicted Functional Partners:
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 | C1orf50 | chromosome 1 open reading frame 50 (199 aa) |
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0.658 | ||||||||||
 | KLHDC10 | kelch domain containing 10 (442 aa) |
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0.618 | ||||||||||
 | CDC42BPG | CDC42 binding protein kinase gamma (DMPK-like); May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity) (1551 aa) |
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0.535 | ||||||||||
 | KBTBD5 | kelch repeat and BTB (POZ) domain containing 5 (621 aa) |
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0.517 | |||||||||
 | C21orf58 | chromosome 21 open reading frame 58 (322 aa) |
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0.509 | ||||||||||
 | FAM124A | family with sequence similarity 124A (582 aa) |
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0.509 | ||||||||||
 | SLC37A1 | solute carrier family 37 (glycerol-3-phosphate transporter), member 1 (533 aa) |
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0.504 | ||||||||||
 | SLC22A18AS | solute carrier family 22 (organic cation transporter), member 18 antisense (253 aa) |
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0.504 | ||||||||||
 | GALNS | galactosamine (N-acetyl)-6-sulfate sulfatase (522 aa) |
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0.482 | ||||||||||
 | BIRC6 | baculoviral IAP repeat containing 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the [...] (4857 aa) |
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0.481 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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